{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:23:59Z","timestamp":1771579439538,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":171,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An 8-year-old male neutered 37.4\u2009kg mixed breed dog was presented for suspected ingestion of a large amount of naproxen (estimated at 235\u2013294\u2009mg\/kg). The dog was treated using a combination of therapeutic plasma exchange (TPE) and plasmaperfusion (PP). The exchange of 2 plasma volumes during 140\u2009min of TPE resulted in a 46% decrease in blood naproxen concentration. Treatment of 1 plasma volume during the following 90\u2009min of PP resulted in an additional 10.3% decrease in naproxen concentration. The patient developed mild gastrointestinal (GI) signs that were treated medically and was successfully discharged after 4\u2009days of hospitalization with normal follow-up laboratory test results and physical examination findings. The combination of extracorporeal treatments decreased the plasma concentration of naproxen, but the additional decrease from PP may not have provided substantial benefit compared with other conventional treatments. No reports of PP, as an alternative to hemoperfusion (HP), in veterinary medicine currently are available.<\/jats:p>","DOI":"10.1111\/jvim.70235","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T15:59:37Z","timestamp":1756569577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Naproxen Overdose Using Therapeutic Plasma Exchange and Plasmaperfusion in a Dog"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9345-8413","authenticated-orcid":false,"given":"Kelsea A.","family":"Studer","sequence":"first","affiliation":[{"name":"Red Bank Veterinary Hospital , Red Bank, New Jersey,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Iacovetta","sequence":"additional","affiliation":[{"name":"Red Bank Veterinary Hospital , Red Bank, New 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