{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:04:29Z","timestamp":1780913069574,"version":"3.54.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":103,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many histological tests have been correlated with outcome in mast cell tumors (MCTs)in dogs, but their statistical independence is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical value of histological factors in the prognostication of dogs with MCTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred and ninety-seven dogs with 199 histologically diagnosed cutaneous (n\u2009=\u2009153) and subcutaneous (n\u2009=\u200943) MCTs treated surgically in primary care practice. All had a commercial prognostic panel performed (Patnaik and Kiupel grade, mitotic count, Ki67, AgNOR, KiAg, c-kit mutation in exons 8 and 11 and KIT localization).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study identifying dogs from searching a commercial laboratory's records (January 2017\u2013August 2020). Follow-up was collected from clinical records. Outcome measures included MCT specific survival (MSS) and recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariable Cox proportional hazard regression identified only mitotic count &amp;gt;\u20095 (HR 10.2; 95% CI 3.2\u201332.8; p\u2009&amp;lt;\u20090.001) predicted poorer MSS across all MCTs. In Patnaik grade I or II and Kiupel low-grade cutaneous MCTs, only c-kit mutation in exon 11 (HR 20.8; 95% CI 1.80\u2013224.8; p\u2009=\u20090.015) predicted MSS. A c-kit mutation in exon 11 (HR 10.0; 95% CI 3.0\u201332.9; p\u2009&amp;lt;\u20090.001), age, and histological tumor free margins &amp;lt;\u20092\u2009mm independently predicted cutaneous and subcutaneous MCT recurrence. In Patnaik grade I or II, and Kiupel low-grade cutaneous MCTs, c-kit mutation in exon 11 (HR 23.20; 95% CI 2.3\u2013231.3; p\u2009=\u20090.007) and AgNOR (HR 13.73; 95% CI 1.6\u2013115.6; p\u2009=\u20090.016) predicted MCT recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>This study suggests a comparatively greater role of c-kit mutations in exon 11 and AgNOR in the prognostication of MCTs, while Ki67 appears less important.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70244","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:45:37Z","timestamp":1760597137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Value of Various Histological Factors in Cutaneous and Subcutaneous Mast Cell Tumors in 197 Dogs"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0210-1398","authenticated-orcid":false,"given":"Katherine","family":"Boyd","sequence":"first","affiliation":[{"name":"Bristol Vet Specialists , Bristol,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Dobromylskyj","sequence":"additional","affiliation":[{"name":"Finn Pathologists , Norfolk,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imogen","family":"Schofield","sequence":"additional","affiliation":[{"name":"CVS , Norfolk,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Royal Veterinary College , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Figueroa","sequence":"additional","affiliation":[{"name":"The Ralph Veterinary Referral Centre , Marlow,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Davies","sequence":"additional","affiliation":[{"name":"Bristol Vet Specialists , Bristol,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"issue":"6","key":"2026021205140806400_jvim70244-bib-0001","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1751-0813.1987.tb09673.x","article-title":"Skin Neoplasms of Dogs in Sydney","volume":"64","author":"Rothwell","year":"1987","journal-title":"Australian Veterinary Journal"},{"issue":"6","key":"2026021205140806400_jvim70244-bib-0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0007-1935(86)90002-3","article-title":"Neoplasms of the Skin Aand Subcutaneous Tissues in Dogs and Cats","volume":"142","author":"Bostock","year":"1986","journal-title":"British Veterinary 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