{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:58:05Z","timestamp":1783051085266,"version":"3.54.6"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":171,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Agria and the Swedish Kennel Club\u2019s Research Fund","award":["N2015-0052"],"award-info":[{"award-number":["N2015-0052"]}]},{"name":"The Fund of Scientific Studies in Companion Animals, University of Copenhagen","award":["A5567"],"award-info":[{"award-number":["A5567"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Arterial thromboembolism (ATE) is a known complication of cardiomyopathies (CM) in cats. Hypercoagulability is believed to be one predisposing factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Assess applicability of global hemostatic tests for evaluating the systemic hemostatic state in cats with CM with concurrent ATE (CM\u2009+\u2009ATE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Six cats with CM\u2009+\u2009ATE, 11 cats with CM, and 13 healthy cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective case\u2013control study (2016\u20132020). Echocardiography, whole blood thromboelastography (TEG), and thrombin generation testing (TGT) were performed. Hypercoagulability was defined for TEG as shortened reaction time (R), shortened kinetics (K), increased angle, or increased maximal amplitude and for TGT as decreased lag time, decreased time to peak, increased peak, or increased endogenous thrombin potential (ETP). If \u2265\u20091 parameter showed significant hypercoagulability compared with healthy cats, and no parameter showed significant hypocoagulability, the patient was considered hypercoagulable. The opposite criteria defined hypocoagulability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hypocoagulability was detected for cats with CM\u2009+\u2009ATE compared with both cats with CM and healthy cats, characterized by significantly prolonged R and K on TEG as well as significantly increased time-to-peak and decreased peak and ETP on TGT. Additionally, some thrombocytopenia was considered likely in cats with CM\u2009+\u2009ATE, but could not be fully evaluated because of a high prevalence of concurrent platelet aggregation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>A systemic hypocoagulable state was detected in cats with CM with concurrent ATE. Similar hemostatic paradoxes in human patients with thrombosis have been suggested to be related to platelet exhaustion, local endocardial hypercoagulability, or alterations in regulatory proteins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70250","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:00:43Z","timestamp":1758513643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Applicability of Global Hemostatic Tools for Evaluation of Hemostatic State and Detection of Thrombosis in Cats With Cardiomyopathies"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7833-5191","authenticated-orcid":false,"given":"Rebecca","family":"Langhorn","sequence":"first","affiliation":[{"name":"University of Copenhagen Department of Veterinary Clinical Sciences, , Frederiksberg C,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-8339","authenticated-orcid":false,"given":"Maiken B. 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