{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T18:35:57Z","timestamp":1775759757899,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":103,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Remdesivir and GS-441524 have successfully treated cats with feline infectious peritonitis (FIP) but the changes in associated signs of ocular disease are not reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Evaluate the response of FIP-associated signs of ocular disease before and after treatment with remdesivir, GS-441524, or both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-one cats diagnosed with FIP by the Internal Medicine services between October 2021 and December 2022 that were treated with injectable, oral, or a combination of anti-viral therapies were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observation study. Signalment, associated signs of ocular disease, treatment, outcome, and follow-up of affected cats were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Associated signs of ocular disease in cats with FIP were diagnosed in 33% (20\/61) cats, with a median follow-up of 55\u2009days (IQR 47.3\u201390.8, range: 16\u20131071\u2009days) in 11 cats with FIP. Ocular changes were all associated with uveitis, of which 20% (4\/20) had anterior uveitis, 25% (5\/20) had posterior uveitis, and 55% (11\/20) had panuveitis. Ocular disease occurred in effusive (11\/20; 55%) and non-effusive (9\/20; 45%) FIP and was bilateral in 70% (14\/20) cats. All cats started an 84-day course of treatment, with the majority (17\/20; 85%) receiving remdesivir in the initial period. Of those, 70% (12\/17) received a high dose of 15\u201320\u2009mg\/kg\/day. Eleven cats with uveitis had long-term follow-up nine (9\/11; 82%) of these had resolution of uveitis. Eighty-seven percent (13\/15) of cases with anterior uveitis received topical anti-inflammatory medication. Eighty percent (16\/20) of cats survived.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Cats with FIP commonly have ocular involvement. Associated uveitis responded to remdesivir or GS-441524 treatment effectively in 82% of cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70253","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:34:08Z","timestamp":1759386848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment With Remdesivir Alone or in Combination With GS-441524 in Cats With Ocular Involvement of Feline Infectious Peritonitis: An Observational Case Series"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5536-7692","authenticated-orcid":false,"given":"Amy L. M. M.","family":"Andrews","sequence":"first","affiliation":[{"name":"Royal Veterinary College, Queen Mother Hospital for Animals, Ophthalmology Service Department of Clinical Science and Research, , Hatfield, Hertfordshire,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eneko","family":"Izaguirre","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, Queen Mother Hospital for Animals, Ophthalmology Service Department of Clinical Science and Research, , Hatfield, Hertfordshire,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie","family":"Green","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals, Internal Medicine Service, Royal Veterinary College Department of Clinical Science and Research, , Hatfield, Hertfordshire,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Scurrell","sequence":"additional","affiliation":[{"name":"Cytopath, Veterinary Pathology Ltd , Ledbury, Herefordshire,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savina","family":"Gogova","sequence":"additional","affiliation":[{"name":"North Down Specialist Referrals, Bletchingley, United Kingdom (Previous Affiliation). Bristol Vet Specialists Ophthalmology Service , Bristol,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7563-8672","authenticated-orcid":false,"given":"Sarah","family":"Tayler","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals, Internal Medicine Service, Royal Veterinary College Department of Clinical Science and Research, , Hatfield, Hertfordshire,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Kafarnik","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, Queen Mother Hospital for Animals, Ophthalmology Service Department of Clinical Science and Research, , Hatfield, 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