{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:19:35Z","timestamp":1770747575026,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T00:00:00Z","timestamp":1350259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kansas State University Mentored Clinical"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>The objective of this study was to assess the pharmacokinetic profile and determine whether any adverse effects would occur in seven healthy adult horses following oral meloxicam tablet administration once daily for 14\u00a0days at a dose of 0.6\u00a0mg\/kg\u00b7bwt. Horses were evaluated for health using physical examination, complete blood count, serum chemistry, urinalysis, and gastroscopy at the beginning and end of the study. Blood was collected for the quantification of meloxicam concentrations with liquid chromatography and mass spectrometry. The mean terminal half\u2010life was 4.99\u00a0\u00b1\u00a01.11\u00a0h. There was no significant difference between the mean<jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content><\/jats:italic><jats:sub>max<\/jats:sub>, 1.58\u00a0\u00b1\u00a00.71\u00a0ng\/mL at<jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><\/jats:italic><jats:sub>max<\/jats:sub>3.48\u00a0\u00b1\u00a03.30\u00a0h on day 1, 2.07\u00a0\u00b1\u00a00.94\u00a0ng\/mL at<jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><\/jats:italic><jats:sub>max<\/jats:sub>1.24\u00a0\u00b1\u00a01.24\u00a0h on day 7, and 1.81\u00a0\u00b1\u00a00.76\u00a0ng\/mL at 1.93\u00a0\u00b1\u00a01.30\u00a0h on day 14 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.30). There was a statistically significant difference between the<jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><\/jats:italic><jats:sub>max<\/jats:sub>on the sample days (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). No statistically significant increase in gastric ulcer score or laboratory analytes was noted. Oral meloxicam tablets were absorbed in adult horses, and adverse effects were not statistically significant in this study. Further studies should evaluate the adverse effects and efficacy of meloxicam tablets in a larger population of horses before routine use can be recommended.<\/jats:p>","DOI":"10.1111\/jvp.12021","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T13:32:56Z","timestamp":1350307976000},"page":"376-381","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacokinetics and adverse effects of oral meloxicam tablets in healthy adult horses"],"prefix":"10.1111","volume":"36","author":[{"given":"K. 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G.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"KuKanich","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.1999.tb00961.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.04.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262338601400110"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1755"},{"key":"e_1_2_6_6_1","first-page":"576","article-title":"Pharmacokinetics of meloxicam in animals and the relevance to humans","volume":"26","author":"Busch U.","year":"1998","journal-title":"Drug Metabolism and Disposition"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2460\/javma.1984.184.06.699","article-title":"Phenylbutazone toxicosis in the horse: a clinical study","volume":"184","author":"Collins L.G.","year":"1984","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02110-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01625558"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-0481-57-8-467"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2460\/javma.1983.182.03.263","article-title":"Renal papillary necrosis in horses","volume":"182","author":"Gunson D.E.","year":"1983","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588302000512"},{"key":"e_1_2_6_13_1","first-page":"127","article-title":"Efficacy and safety of firocoxib in the management of canine osteoarthritis under field conditions","volume":"7","author":"Hanson P.D.","year":"2006","journal-title":"Veterinary Therapeutics"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1990.tb03117.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1935(91)90099-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.6.614"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.3.258"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2460\/ajvr.1983.44.05.774","article-title":"Effects of large doses of phenylbutazone administration to horses","volume":"44","author":"MacKay R.J.","year":"1983","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00398.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.11.1496"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","unstructured":"NADA 141\u2010253. 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