{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:26:54Z","timestamp":1772843214814,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"George and Phyllis Miller Feline Health Fund"},{"name":"San Francisco Foundatio"},{"name":"Center for Companion Animal Health, School of Veterinary Medicine, University of California"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>The aim of this study was to examine the effect of the sampling site on the drug concentration\u2013time profile, following intravenous or buccal (often called \u2018oral transmucosal\u2019) drug administration. Buprenorphine (20\u00a0\u03bcg\/kg) was administered IV or buccally to six cats. Blood samples were collected from the carotid artery and the jugular and medial saphenous veins for 24\u00a0h following buprenorphine administration. Buprenorphine concentration\u2013time data were examined using noncompartmental analysis. Pharmacokinetic parameters were compared using the <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ilcoxon signed rank test, applying the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>onferroni correction. Significance was set at <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05. Following <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> administration, no difference among the sampling sites was found. Following buccal administration, maximum concentration [jugular: 6.3 (2.9\u20139.8), carotid: 3.4 (1.9\u20134.9), medial saphenous: 2.5 (1.7\u20134.1) ng\/mL], area under the curve [jugular: 395 (335\u2013747), carotid: 278 (214\u2013693), medial saphenous: 255 (188\u2013608) ng\u00b7min\/mL], and bioavailability [jugular: 47 (34\u201367), carotid: 32 (20\u201352), medial saphenous: 23 (16\u201355)%] were higher in the jugular vein than in the carotid artery and medial saphenous vein. Jugular venous blood sampling is not an acceptable substitute for arterial blood sampling following buccal drug administration.<\/jats:p>","DOI":"10.1111\/jvp.12075","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T12:53:47Z","timestamp":1375188827000},"page":"145-150","source":"Crossref","is-referenced-by-count":33,"title":["Impact of the blood sampling site on time\u2013concentration drug profiles following intravenous or buccal drug administration"],"prefix":"10.1111","volume":"37","author":[{"given":"A. R.","family":"Hedges","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. H.","family":"Pypendop","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Shilo","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Stanley","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System School of Veterinary Medicine University of California Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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