{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:02:31Z","timestamp":1740135751178,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003516","name":"Winn Feline Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100003516","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>The objective of this study was to evaluate the pharmacokinetic properties and adverse effect profile of single\u2010dose oral bosentan, a dual endothelin receptor antagonist, in healthy cats. Pharmacokinetic parameters were determined following a single mean \u00b1 SD oral dose of 3.2 \u00b1 0.6 mg\/kg of bosentan in 6 adult cats. Blood was collected for quantification of bosentan via high\u2010performance liquid chromatography with ultraviolet detection. Blood and urine were evaluated for CBC, plasma biochemical profile, and urinalysis, and repeat physical examinations were performed to evaluate for adverse effects. The mean terminal half\u2010life of bosentan was 20.4 \u00b1 17.2 h. The mean peak plasma concentration was 0.49 \u00b1 0.24 g\/mL, and the mean time to maximum plasma concentration was 6.8 \u00b1 8.6 h. The area under the curve was 5.14 \u00b1 3.81 h\u00b7\u03bcg\/mL. Oral bosentan tablets were absorbed in cats, and no clinically important adverse events were noted. Further evaluation of repeat dosing, investigation into the <jats:italic>in vivo<\/jats:italic> efficacy of decreasing endothelin\u20101 concentrations in cats, as well as safety in conjunction with other medications is warranted.<\/jats:p>","DOI":"10.1111\/jvp.12083","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T11:11:13Z","timestamp":1382613073000},"page":"192-195","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetics and preliminary safety data of a single oral dose of bosentan, a dual endothelin receptor antagonist, in cats"],"prefix":"10.1111","volume":"37","author":[{"given":"N.","family":"Puza","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery College of Veterinary Medicine University of Missouri Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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