{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:24:15Z","timestamp":1788870255665,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"George and Phyllis Miller Feline Health Fund"},{"DOI":"10.13039\/100006623","name":"San Francisco Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006623","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Center for Companion Animal Health, School of Veterinary Medicine, University of California"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>\n                    This study reports the pharmacokinetics of buprenorphine, following i.v. and buccal administration, and the relationship between buprenorphine concentration and its effect on thermal threshold. Buprenorphine (20\u00a0\u03bcg\/kg) was administered intravenously or buccally to six cats. Thermal threshold was determined, and arterial blood sampled prior to, and at various times up to 24\u00a0h following drug administration. Plasma buprenorphine concentration was determined using liquid chromatography\/mass spectrometry. Compartment models were fitted to the time\u2013concentration data. Pharmacokinetic\/pharmacodynamic models were fitted to the concentration\u2010thermal threshold data. Thermal threshold was significantly higher than baseline 44\u00a0min after buccal administration, and 7, 24, and 104\u00a0min after i.v. administration. A two\u2010 and three\u2010compartment model best fitted the data following buccal and i.v. administration, respectively. Following i.v. administration, mean\u00a0\u00b1\u00a0SD volume of distribution at steady\u2010state (L\/kg), clearance (mL\u00b7min\/kg), and terminal half\u2010life (h) were 11.6\u00a0\u00b1\u00a08.5, 23.8\u00a0\u00b1\u00a03.5, and 9.8\u00a0\u00b1\u00a03.5. Following buccal administration, absorption half\u2010life was 23.7\u00a0\u00b1\u00a09.1\u00a0min, and terminal half\u2010life was 8.9\u00a0\u00b1\u00a04.9\u00a0h. An effect\u2010compartment model with a simple effect maximum model best predicted the time\u2010course of the effect of buprenorphine on thermal threshold. Median (range)\n                    <jats:italic>k<\/jats:italic>\n                    <jats:sub>e0<\/jats:sub>\n                    and EC50 were 0.003 (0.002\u20130.018)\/min and 0.599 (0.073\u20131.628) ng\/\n                    <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                    (i.v.), and 0.017 (0.002\u20130.023)\/min and 0.429 (0.144\u20130.556) ng\/\n                    <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                    (buccal).\n                  <\/jats:p>","DOI":"10.1111\/jvp.12084","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T02:51:44Z","timestamp":1383101504000},"page":"252-259","source":"Crossref","is-referenced-by-count":24,"title":["Pharmacokinetics of buprenorphine following intravenous and buccal administration in cats, and effects on thermal threshold"],"prefix":"10.1111","volume":"37","author":[{"given":"A. R.","family":"Hedges","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. H.","family":"Pypendop","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Shilo\u2010Benjamini","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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