{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:56:56Z","timestamp":1788875816902,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Birmingham Racing Commission"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Simultaneous administration of a nonselective<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>inhibitor and a<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 specific<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>has not been previously reported in horses. The goal of this study was to determine the safety of a 10\u2010day dosage regimen of phenylbutazone and firocoxib, both at their standard dosages, in horses. Six horses were administered 2.2\u00a0mg\/kg of phenylbutazone and 0.1\u00a0mg\/kg of firocoxib by mouth, daily for 10\u00a0days. Horses were assessed daily for changes in behavior, appetite, fecal consistency, signs of abdominal pain, and oral mucous membrane ulceration. Horses were assessed prior to and on the last day of treatment for changes in serum creatinine, albumin, total protein, and urine\u2010specific gravity. Horses underwent endoscopic examination of the esophagus, stomach, and pylorus prior to and 24\u00a0hours after the last treatment. A significant change in serum creatinine and total protein was observed on day 10 of treatment. No other significant findings were noted during the experiment. Results indicated that co\u2010administration of phenylbutazone and firocoxib may cause renal disease.<\/jats:p>","DOI":"10.1111\/jvp.12097","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T06:34:44Z","timestamp":1387521284000},"page":"413-416","source":"Crossref","is-referenced-by-count":28,"title":["Evaluation of the safety of a combination of oral administration of phenylbutazone and firocoxib in horses"],"prefix":"10.1111","volume":"37","author":[{"given":"L.","family":"Kivett","sequence":"first","affiliation":[{"name":"Foundation Equine Mobile Medicine and Dentistry Southern Pines NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Taintor","sequence":"additional","affiliation":[{"name":"JT Vaughan Large Animal Teaching Hospital Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wright","sequence":"additional","affiliation":[{"name":"JT Vaughan Large Animal Teaching Hospital Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02741.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2460\/javma.1984.184.06.699","article-title":"Phenylbutazone toxicosis in the horse: a clinical study","volume":"184","author":"Collins L.G.","year":"1984","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2011.01362.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.1.91"},{"key":"e_1_2_2_6_1","volume-title":"Freedom of Information Summary. 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