{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:05:52Z","timestamp":1770977152149,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"crossref","award":["PIP 112-200801-01123"],"award-info":[{"award-number":["PIP 112-200801-01123"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y T\u00e9cnica","doi-asserted-by":"crossref","award":["PICT 1881"],"award-info":[{"award-number":["PICT 1881"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y T\u00e9cnica","doi-asserted-by":"crossref","award":["PICT 1432"],"award-info":[{"award-number":["PICT 1432"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>The family of <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010binding cassette (<jats:styled-content style=\"fixed-case\">ABC<\/jats:styled-content>) transporters is composed of several transmembrane proteins that are involved in the efflux of a large number of drugs including ivermectin, a macrocyclic lactone (<jats:styled-content style=\"fixed-case\">ML<\/jats:styled-content>) endectocide, widely used in human and livestock antiparasitic therapy. The aim of the work reported here was to assess the interaction between three different anthelmintic drugs with substrates of the P\u2010glycoprotein (P\u2010gp) and the breast cancer resistance protein (<jats:styled-content style=\"fixed-case\">BCRP<\/jats:styled-content>). The ability of ivermectin (<jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>), moxidectin (<jats:styled-content style=\"fixed-case\">MOX<\/jats:styled-content>) and closantel (<jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content>) to modulate the intestinal transport of both rhodamine 123 (Rho 123), a P\u2010gp substrate, and danofloxacin (<jats:styled-content style=\"fixed-case\">DFX<\/jats:styled-content>), a <jats:styled-content style=\"fixed-case\">BCRP<\/jats:styled-content> substrate, across rat ileum was studied by performing the Ussing chamber technique. Compared to the controls, Rho 123 efflux was significantly reduced by <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content> (69%), <jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content> (51%) and the positive control <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>833 (65%), whereas no significant differences were observed in the presence of <jats:styled-content style=\"fixed-case\">MOX<\/jats:styled-content> (30%). In addition, <jats:styled-content style=\"fixed-case\">DFX<\/jats:styled-content> efflux was reduced between 59% and 72% by all the assayed drug molecules, showing a higher potency than that observed in the presence of the specific <jats:styled-content style=\"fixed-case\">BCRP<\/jats:styled-content> inhibitor pantoprazole (<jats:styled-content style=\"fixed-case\">PTZ<\/jats:styled-content>) (52%). An <jats:italic>ex vivo<\/jats:italic> intestinal transport approach based on the diffusion chambers technique may offer a complementary tool to study potential drug interactions with efflux transporters such as P\u2010gp and <jats:styled-content style=\"fixed-case\">BCRP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvp.12112","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T10:50:49Z","timestamp":1394448649000},"page":"332-337","source":"Crossref","is-referenced-by-count":15,"title":["Intestinal drug transport: <i>ex vivo<\/i> evaluation of the interactions between <scp>ABC<\/scp> transporters and anthelmintic molecules"],"prefix":"10.1111","volume":"37","author":[{"given":"M.","family":"Ballent","sequence":"first","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Centro de Investigaci\u00f3n Veterinaria de Tandil Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Facultad de Ciencias Veterinarias UNCPBA Tandil Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mat\u00e9","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Centro de Investigaci\u00f3n Veterinaria de Tandil Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Facultad de Ciencias Veterinarias UNCPBA Tandil Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Virkel","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Centro de Investigaci\u00f3n Veterinaria de Tandil Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Facultad de Ciencias Veterinarias UNCPBA Tandil Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sallovitz","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Centro de Investigaci\u00f3n Veterinaria de Tandil Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Facultad de Ciencias Veterinarias UNCPBA Tandil Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Viviani","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Centro de Investigaci\u00f3n Veterinaria de Tandil Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Facultad de Ciencias Veterinarias UNCPBA Tandil Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lanusse","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Centro de Investigaci\u00f3n Veterinaria de Tandil Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Facultad de Ciencias Veterinarias UNCPBA Tandil Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lifschitz","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Centro de Investigaci\u00f3n Veterinaria de Tandil Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas Facultad de Ciencias Veterinarias UNCPBA Tandil Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720106776359195"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2007.00848.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.09.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2002.00400.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2006.00738.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2006.00721.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.05.013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.6.1288"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.62.070193.002125"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb12844.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2005.00655.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.05.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002202990400038X"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.030700"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.6.626"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1997.00825.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1997.tb06084.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.11.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2006.10.004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2002.00396.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357022421"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.01.009"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.04.039"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704560"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-8-927"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2010.01170.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.008219"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9632-1"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.02.009"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(96)00656-9"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2012.04.001"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2010.01241.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00169-2"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706974"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.02.004"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:34:15Z","timestamp":1696167255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jvp.12112"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12112","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,10]]}}}