{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:43:06Z","timestamp":1770219786844,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Analytical Pharmacology Laboratory"},{"name":"Kansas State University"},{"name":"Kansas State University Veterinary Research Scholar Program"},{"name":"Kurz Merial Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Sucralfate and minocycline may be administered concurrently to dogs. The relative bioavailability of tetracyclines may be reduced if administered with sucralfate, but studies confirming these interactions in dogs are not available. This study evaluated the pharmacokinetics of oral minocycline in dogs (M), determined the effects of concurrent administration of sucralfate and minocycline (MS) on minocycline pharmacokinetics, determined the effects of delaying sucralfate administration by 2\u00a0h (MS+2) on minocycline pharmacokinetics, and established dosing recommendations based on pharmacodynamic indices. Oral minocycline (300\u00a0mg) and sucralfate suspension (1\u00a0g) were administered to five greyhounds in a randomized crossover design. Minocycline plasma concentrations were evaluated using liquid chromatography with mass spectrometry. The maximum plasma concentration (C<jats:sub>MAX<\/jats:sub>) and area under the curve (AUC) of minocycline were 1.15\u00a0\u03bcg\/mL and 8.0\u00a0h* \u03bcg\/mL, respectively. The C<jats:sub>MAX<\/jats:sub>and AUC were significantly lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in the MS group (C<jats:sub>MAX<\/jats:sub>\u00a0=\u00a00.33\u00a0\u03bcg\/mL, AUC 3.0\u00a0h*\u03bcg\/mL) compared with M or MS+2 (C<jats:sub>MAX<\/jats:sub>= 0.97\u00a0\u03bcg\/mL, AUC 10.3\u00a0h*\u03bcg\/mL). Delaying sucralfate by 2\u00a0h did not decrease oral minocycline absorption, but concurrent administration significantly decreased minocycline absorption. A dose of 7.5\u00a0mg\/kg p.o. q12\u00a0h achieves the pharmacodynamic index for a bacterial minimum inhibitory concentration (MIC) of 0.25\u00a0\u03bcg\/mL (AUC:MIC\u226533.9).<\/jats:p>","DOI":"10.1111\/jvp.12116","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T10:50:43Z","timestamp":1394448643000},"page":"451-456","source":"Crossref","is-referenced-by-count":14,"title":["Effect of sucralfate on oral minocycline absorption in healthy dogs"],"prefix":"10.1111","volume":"37","author":[{"given":"K.","family":"KuKanich","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"KuKanich","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology College of Veterinary Medicine Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Kansas State University Manhattan KS USA"},{"name":"Small Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00922-07"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1128\/AAC.43.4.813","article-title":"Efficacy of doxycycline, azithromycin, or trovafloxacin for treatment of experimental Rocky Mountain spotted fever in dogs","volume":"43","author":"Breitschwerdt E.B.","year":"1999","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.11.1901"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb01944.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.5.931"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198206000-00002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.2.248"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01622-09"},{"key":"e_1_2_6_10_1","first-page":"715","volume-title":"Saunders Handbook of Veterinary Drugs","author":"Papich M.G.","year":"2011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12002"},{"key":"e_1_2_6_12_1","first-page":"1038","volume-title":"Veterinary Drug Handbook","author":"Plumb D.C.","year":"2005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90452-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.848-853.2002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.2460\/ajvr.1985.46.06.1316","article-title":"Compartmental and noncompartmental pharmacokinetics analyses of minocycline hydrochloride in the dog","volume":"46","author":"Wilson R.C.","year":"1985","journal-title":"American Journal of Veterinary Research"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:57:09Z","timestamp":1746147429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,10]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/jvp.12116"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12116","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,10]]}}}