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Our hypothesis was that, if closantel possesses thyroid hormone\u2010like activity, its use under <jats:italic>in vivo<\/jats:italic> conditions will result in changes similar to those in hyperthyroidism. The study was conducted in 20 Jezersko\u2010Solchava breed sheep. Blood sampling was performed before and 10\u00a0days after routine anthelmintic treatment with closantel. Complete blood count, plasma cholesterol, triglycerides, protein, and albumin levels, as well as those of serum T3 and T4, were compared before and 10\u00a0days after closantel administration. This routine anthelmintic treatment of sheep with closantel did not significantly influence hematological parameters, thyroid hormone levels, or most of the biochemical parameters. No evidence was found for thyroid hormone\u2010like activity of closantel in sheep. However, significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) elevated levels of plasma triglycerides were present 10\u00a0days after closantel administration.<\/jats:p>","DOI":"10.1111\/jvp.12188","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T07:09:18Z","timestamp":1416467358000},"page":"297-300","source":"Crossref","is-referenced-by-count":0,"title":["Does closantel in therapeutic doses display thyroid hormone\u2010like activity in sheep?"],"prefix":"10.1111","volume":"38","author":[{"given":"T.","family":"Snoj","sequence":"first","affiliation":[{"name":"Institute of Physiology, Pharmacology and Toxicology Veterinary Faculty University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Cebulj\u2010Kadunc","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Pharmacology and Toxicology Veterinary Faculty University of Ljubljana Ljubljana 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