{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T21:07:01Z","timestamp":1719868021409},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Large Animal Clinical Sciences"},{"name":"Texas A&M University College of Veterinary Medicine"},{"name":"Biomedical Sciences"},{"name":"College Station"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>The objectives of this study were to determine plasma concentrations and pharmacokinetic parameters of tulathromycin after a single subcutaneous administration in the cervical region in sheep using the cattle labeled dose of 2.5\u00a0mg\/kg. Six adult healthy ewes were administered tulathromycin on day 0. Blood samples were collected just prior to dosing and at selected time points for 360\u00a0h. Plasma samples were analyzed to determine tulathromycin concentrations, and noncompartmental analysis was performed for pharmacokinetic parameters. The mean maximum plasma concentration was 3598\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, the mean time to maximum concentration was 1.6\u00a0h, and the apparent elimination half\u2010life ranged from 68.1 to 233.1\u00a0h (mean 118\u00a0h). When comparing our results to goats and cattle, it appears sheep are more similar to cattle in regard to the concentrations observed and pharmacokinetic parameters. In summary, the pharmacokinetics of tulathromycin in sheep appear to be similar enough to those in goats and cattle to recommend similar dosing (2.5\u00a0mg\/kg SC), assuming that the target pathogens have similar inhibitory concentrations.<\/jats:p>","DOI":"10.1111\/jvp.12196","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T15:27:37Z","timestamp":1418138857000},"page":"414-416","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacokinetics of tulathromycin in nonpregnant adult ewes"],"prefix":"10.1111","volume":"38","author":[{"given":"K.","family":"Washburn","sequence":"first","affiliation":[{"name":"Large Animal Clinical Sciences Texas A&amp;M University College of Veterinary Medicine and Biomedical Sciences College Station TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. R.","family":"Fajt","sequence":"additional","affiliation":[{"name":"Veterinary Physiology and Pharmacology Texas A&amp;M University College of Veterinary Medicine and Biomedical Sciences College Station TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Coetzee","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic and Production Animal Medicine Iowa State University College of Veterinary Medicine Ames IA USA"},{"name":"Pharmacology Analytical Support Team (PhAST) Veterinary Diagnostic Laboratory Iowa State University College of Veterinary Medicine Ames IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rice","sequence":"additional","affiliation":[{"name":"Pharmacology Analytical Support Team (PhAST) Veterinary Diagnostic Laboratory Iowa State University College of Veterinary Medicine Ames IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. W.","family":"Wulf","sequence":"additional","affiliation":[{"name":"Pharmacology Analytical Support Team (PhAST) Veterinary Diagnostic Laboratory Iowa State University College of Veterinary Medicine Ames IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Washburn","sequence":"additional","affiliation":[{"name":"Veterinary Physiology and Pharmacology Texas A&amp;M University College of Veterinary Medicine and Biomedical Sciences College Station TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2010.01261.x"},{"key":"e_1_2_3_3_1","first-page":"129","article-title":"Rapid and prolonged distribution of Tulathromycin into lung homogenate and pulmonary epithelial lining fluid of Holstein calves following a single subcutaneous administration of 2.5\u00a0mg\/kg body weight","volume":"8","author":"Cox S.R.","year":"2010","journal-title":"International Journal of Applied Research in Veterinary Medicine"},{"key":"e_1_2_3_4_1","first-page":"60","article-title":"Pharmacokinetics and lung tissue concentrations of tulathromycin, a new triamilide antibiotic, in cattle","volume":"5","author":"Nowakowski M.A.","year":"2004","journal-title":"Veterinary Therapeutics"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.10.1634"},{"issue":"2","key":"e_1_2_3_6_1","first-page":"40","article-title":"Consideration of sheep as a minor species: comparison of drug metabolism and disposition with other domestic ruminants","volume":"35","author":"Short C.R.","year":"1993","journal-title":"Veterinary and Human Toxicology"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/tvjl.1999.0401"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.234.9.1162"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2010.06.025"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:20:16Z","timestamp":1696285216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,9]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/jvp.12196"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12196","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,9]]}}}