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Body fluid and plasma drug concentrations were determined by high\u2010performance liquid chromatography (<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>). Mild to moderate gastrointestinal adverse effects were seen. The mean <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u201324<\/jats:sub>: minimum inhibitory concentration (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>) ratio was 15.23 for a chosen <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> of 1\u00a0\u03bcg\/mL, which is lower than the recommended target of 20\u201325 and also lower than previously reported in dogs, perhaps reflecting induction of metabolizing enzymes by multiple dosing. Voriconazole concentrations in the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>, aqueous humor, and synovial fluid were only 13\u201330% the concurrent plasma concentration, which is lower than previously reported in other species. Results of this study suggest that twice daily, administration may be necessary to maintain therapeutic plasma concentrations in dogs but further studies are warranted.<\/jats:p>","DOI":"10.1111\/jvp.12208","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T07:15:31Z","timestamp":1424243731000},"page":"451-456","source":"Crossref","is-referenced-by-count":18,"title":["Pharmacokinetics and distribution of voriconazole in body fluids of dogs after repeated oral dosing"],"prefix":"10.1111","volume":"38","author":[{"given":"J. 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