{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:57:52Z","timestamp":1789660672655,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ott Endowment"},{"name":"DNA Bank"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>The aim of this study was to sequence all exons of the<jats:italic><jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>1<\/jats:italic>(<jats:italic><jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content><\/jats:italic>1) gene in cats that had experienced adverse reactions to P\u2010glycoprotein substrate drugs (phenotyped cats). Eight phenotyped cats were included in the study consisting of eight cats that experienced central nervous system toxicosis after receiving ivermectin (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), a combination product containing moxidectin and imidacloprid (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), a combination product containing praziquantel and emodepside (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) or selamectin (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), and 1 cat that received the product containing praziquantel and emodepside but did not experience toxicity (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). Fifteen exons contained polymorphisms and twelve exons showed no variation from the reference sequence. The most significant finding was a nonsense mutation (<jats:italic><jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>1<\/jats:italic>1930_1931del<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>) in one of the ivermectin\u2010treated cats. This cat was homozygous for the deletion mutation. All of the other phenotyped cats were homozygous for the wild\u2010type allele. However, 14 missense mutations were identified in one or more phenotyped cats.<jats:italic><jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>1<\/jats:italic>1930_1931del<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>was also identified in four nonphenotyped cats (one homozygous and three heterozygous for the mutant allele). Cats affected by<jats:italic><jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>1<\/jats:italic>1930_1931del<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>would be expected to have a similar phenotype as dogs with the previously characterized<jats:italic><jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content><\/jats:italic>1\u20101\u0394 mutation.<\/jats:p>","DOI":"10.1111\/jvp.12212","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T05:32:22Z","timestamp":1423459942000},"page":"429-433","source":"Crossref","is-referenced-by-count":38,"title":["Identification of a nonsense mutation in feline<i><scp>ABCB<\/scp>1<\/i>"],"prefix":"10.1111","volume":"38","author":[{"given":"K. L.","family":"Mealey","sequence":"first","affiliation":[{"name":"Program in Individualized Medicine Department of Veterinary Clinical Sciences College of Veterinary Medicine Washington State University Pullman WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. S.","family":"Burke","sequence":"additional","affiliation":[{"name":"Program in Individualized Medicine Department of Veterinary Clinical Sciences College of Veterinary Medicine Washington State University Pullman WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2009.01068.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12149"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443090-00001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.8086"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2008.00964.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200111000-00012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.018978"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402374101"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.2460\/ajvr.1987.48.04.684","article-title":"Clinical observations in collies given ivermectin orally","volume":"48","author":"Paul A.J.","year":"1987","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2009.00972.x"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T15:32:16Z","timestamp":1747582336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,9]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/jvp.12212"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12212","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,9]]}}}