{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:24:35Z","timestamp":1767907475976,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>The current available formulations of itraconazole are not ideal for dosing in cats. The capsular preparation often does not allow for accurate dosing, the oral solution is difficult to administer and poorly tolerated, and the bioavailability of compounded formulations has been shown to be poor in other species. The aim of this study was to evaluate every other day dosing of 100\u00a0mg itraconazole capsule in healthy adult cats. Ten healthy adult cats received a 100\u00a0mg capsule of itraconazole orally every 48\u00a0h for 8\u00a0weeks. Peak and trough serum concentrations of itraconazole were measured weekly using high\u2010performance liquid chromatography (<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>). Physical examination, complete blood count (<jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>), and chemistry profiles were performed weekly. The dosage regimen achieved average therapeutic trough concentrations (&gt;0.5\u00a0<jats:italic>\u03bc<\/jats:italic>g\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) within 3\u00a0weeks. The protocol yielded no adverse effects in 8 of the 10 study cats, with affected cats recovering fully with discontinuation of the drug and supportive care. At 8\u00a0weeks, an average peak concentration of 1.79\u00a0\u00b1\u00a00.952\u00a0<jats:italic>\u03bc<\/jats:italic>g\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>(95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.996\u20132.588) and an average trough concentration of 0.761\u00a0\u00b1\u00a00.540\u00a0<jats:italic>\u03bc<\/jats:italic>g\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>(95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.314\u20131.216) were achieved. Overall, a 100\u00a0mg every other day oral dosage regimen for itraconazole in cats yielded serum concentrations with minimal fluctuation and with careful monitoring may be considered for treatment of cats with systemic fungal disease.<\/jats:p>","DOI":"10.1111\/jvp.12231","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T05:19:47Z","timestamp":1428902387000},"page":"27-31","source":"Crossref","is-referenced-by-count":15,"title":["Alternate\u2010day dosing of itraconazole in healthy adult cats"],"prefix":"10.1111","volume":"39","author":[{"given":"S. M.","family":"Middleton","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine University of Illinois Urbana IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kubier","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Center Melbourne FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Dirikolu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine University of Illinois Urbana IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Papich","sequence":"additional","affiliation":[{"name":"Molecular Biomedical Sciences Department College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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