{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:41:53Z","timestamp":1762101713190,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001655","name":"Grayson Jockey Club Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001655","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Omeprazole is widely used in the treatment of equine gastric ulcer syndrome. To date, little is known about the relative pharmacokinetics of the different formulations making comparisons between products difficult. The objectives of the study were to investigate the relative pharmacokinetics of five commercially available formulations of omeprazole in the horse and to test for bioequivalence of four of the formulations using one of the formulations as a reference standard. Twelve mature<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>horoughbred horses were fasted for 16\u00a0h then administered 2\u00a0g of each formulation in a cross\u2010over design. Serial blood samples were collected and plasma omeprazole concentration was determined by ultra high\u2010performance liquid chromatography\u2013mass spectrometry (UHPLC\u2010MS). No significant differences were present between three of the formulations and the reference formulation, while the fourth formulation had a lower<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content><jats:sub>max<\/jats:sub>and longer<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:sub>max<\/jats:sub>than the reference formulation. Bioequivalence against the reference formulation could not be demonstrated for any of the formulations tested. The findings of the study suggested that the method of protection utilised by different formulations of omeprazole (enteric\u2010coated granules vs. buffering) does not significantly alter the pharmacokinetics of the drug. Further work to establish bioequivalence is needed before direct comparisons can be drawn between different formulations.<\/jats:p>","DOI":"10.1111\/jvp.12240","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T09:18:48Z","timestamp":1432027128000},"page":"78-83","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacokinetics and bioequivalence testing of five commercial formulations of omeprazole in the horse"],"prefix":"10.1111","volume":"39","author":[{"given":"B. W.","family":"Sykes","sequence":"first","affiliation":[{"name":"School of Veterinary Sciences The University of Queensland Gatton Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Underwood","sequence":"additional","affiliation":[{"name":"School of Veterinary Sciences The University of Queensland Gatton Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Greer","sequence":"additional","affiliation":[{"name":"School of Veterinary Sciences The University of Queensland Gatton Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"McGowan","sequence":"additional","affiliation":[{"name":"Institute of Ageing and Chronic Disease University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Mills","sequence":"additional","affiliation":[{"name":"School of Veterinary Sciences The University of Queensland Gatton Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb05176.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12341"},{"issue":"29","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.2042-3306.1999.tb05171.x","article-title":"Effect of omeprazole paste on gastric acid secretion in horses","volume":"31","author":"Daurio C.P.","year":"1999","journal-title":"Equine Veterinary Journal"},{"issue":"13","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.2042-3306.1992.tb04794.x","article-title":"Pharmacokinetics and antisecretory effects of intravenous omeprazole in horses","volume":"24","author":"Jenkins C.C.","year":"1992","journal-title":"Equine Veterinary Journal"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1636"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.4.270"},{"issue":"29","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.2042-3306.1999.tb05175.x","article-title":"Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial","volume":"31","author":"MacAllister C.G.","year":"1999","journal-title":"Equine Veterinary Journal Supplement"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516403775696339"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1997.tb03153.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2001.tb00105.x"},{"key":"e_1_2_9_12_1","first-page":"669","volume-title":"Large Animal Internal Medicine","author":"Sykes B.W.","year":"2014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12083"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12191"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12169"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12287"},{"key":"e_1_2_9_17_1","unstructured":"The European Agency for the Evaluation of Medicinal Products(2001)Guidelines for the conduct of bioequivalence studies for veterinary medicinal products pp.1\u201311. Available at:www.eudra.org\/emea.html."},{"issue":"29","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.2042-3306.1999.tb05177.x","article-title":"Clinical trial to determine the effect of omeprazole given once or twice daily on gastric ulceration","volume":"31","author":"Vatistas N.J.","year":"1999","journal-title":"Equine Veterinary Journal Supplement"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.01.007"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12240","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T03:02:13Z","timestamp":1717902133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,19]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/jvp.12240"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12240","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"type":"print","value":"0140-7783"},{"type":"electronic","value":"1365-2885"}],"subject":[],"published":{"date-parts":[[2015,5,19]]}}}