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Inhibition of P\u2010gp can lead to changes in pharmacokinetics of drugs (drug\u2013drug interactions), which can lead to toxicity and adverse side effects. This study aimed to establish a functional assay to measure the inhibitory potential of veterinary drugs on feline P\u2010gp by means of fluorescence\u2010associated flow cytometry of feline lymphoma cells. In this model, <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>833 and ivermectin potently inhibited P\u2010gp function; cyclosporine and verapamil moderately inhibited P\u2010gp function, whereas ketoconazole, itraconazole, diazepam, and its metabolites had no effect on P\u2010gp function. This model can be used for testing the inhibitory potency of (new) drugs on feline P\u2010gp.<\/jats:p>","DOI":"10.1111\/jvp.12248","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T05:23:37Z","timestamp":1437369817000},"page":"95-97","source":"Crossref","is-referenced-by-count":4,"title":["A functional model for feline P\u2010glycoprotein"],"prefix":"10.1111","volume":"39","author":[{"given":"C. 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