{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:02:35Z","timestamp":1773691355491,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MSD Animal Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm & Therapeutics"],"published-print":{"date-parts":[[2016,4]]},"abstract":"The penetration of antimicrobials in pig tonsils is hardly known. The objective of the study was to quantify the tildipirosin (TD<\/jats:styled-content>) penetration in tonsils. Animals were randomly divided into six groups (control, T1, T2 (1), T2(5), T2(10), and T2(15)) of eight animals. T1 and T2 groups received a dose of 2 and 4\u00a0mg of TD<\/jats:styled-content>\/kg bw in one shot (Zuprevo\u00ae<\/jats:sup> MSD<\/jats:styled-content> Animal Health), respectively, and the control group received 2\u00a0mL of saline solution. The animals were sacrificed by intravenous administration of pentobarbital sodium 24\u00a0h after finishing the treatment for the control, T1, and T2(1) groups, whereas animals of T2(5), T2(10), and T2(15) groups were sacrificed at 5, 10, and 15\u00a0days, post\u2010treatment, respectively. Tonsils and blood samples were taken at necropsy to obtain plasma, and the tildipirosin concentration was determined by high\u2010performance liquid chromatography with tandem mass spectrometry detection. The concentration in plasma was always significantly lower than in tonsil. Average TD<\/jats:styled-content> tonsil concentrations increased significantly in a dose\u2010dependent manner, and the tonsil TD<\/jats:styled-content> vs. plasma TD<\/jats:styled-content> concentration ratio was approximately 75 for the doses of 2 and 4\u00a0mg of TD<\/jats:styled-content>\/kg bw at 24\u00a0h post\u2010treatment. Moreover, the maximum concentration of tildipirosin in tonsil was observed at 1\u00a0day postadministration, and this concentration decreased gradually from this day until 15\u00a0days postadministration for the dose of 4\u00a0mg of TD<\/jats:styled-content>\/kg bw. Finally, the ratio AUC<\/jats:styled-content>tonsil<\/jats:sub>\/AUC<\/jats:styled-content>plasma<\/jats:sub> was 97.9, and the T<\/jats:italic>1\/2 (h)<\/jats:sub> was clearly higher in tonsil than in plasma.<\/jats:p>","DOI":"10.1111\/jvp.12258","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T11:53:21Z","timestamp":1439380401000},"page":"199-201","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacokinetics of tildipirosin in pig tonsils"],"prefix":"10.1111","volume":"39","author":[{"given":"F.","family":"Torres","sequence":"first","affiliation":[{"name":"Departament de Producci\u00f3 Animal ETSEA University de Lleida Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Technical Service MSD Animal Health Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Technical Service MSD Animal Health Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Menj\u00f3n","sequence":"additional","affiliation":[{"name":"Technical Service MSD Animal Health Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ibanez","sequence":"additional","affiliation":[{"name":"Marketing Manager MSD Animal Health Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Collell","sequence":"additional","affiliation":[{"name":"MSD Global Swine Summit NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Azlor","sequence":"additional","affiliation":[{"name":"MSD Global Swine Summit NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fraile","sequence":"additional","affiliation":[{"name":"Departament de Producci\u00f3 Animal ETSEA University de Lleida Lleida Spain"},{"name":"Agrotecnio Center Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,12]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.163.15.445"},{"key":"e_1_2_3_3_1","unstructured":"B\u00e6kbo P.(2006)Elimination of respiratory diseases \u2013 a Danish practitioners approach.Proceedings of the 19th IPVS Congress p. 313 16\u201319 July Copenhagen Denmark. vol 1."},{"key":"e_1_2_3_4_1","first-page":"129","article-title":"Rapid and Prolonged distribution of tulathromycin into lung homogenate and pulmonary epithelial lining fluid of Holstein calves following a single subcutaneous administration of 2.5\u00a0mg\/kg bodyweight","volume":"8","author":"Cox S.R.","year":"2010","journal-title":"International Journal of Applied Research in Veterinary Medicine"},{"key":"e_1_2_3_5_1","unstructured":"EMA(2011)CVMP Assessment Report. 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