{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:41:35Z","timestamp":1776192095223,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["NR NN 308575540"],"award-info":[{"award-number":["NR NN 308575540"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>A tulathromycin concentration and pharmacokinetic parameters in plasma and lung tissue from healthy pigs and <jats:italic>Actinobacillus pleuropneumoniae<\/jats:italic> (<jats:italic>App<\/jats:italic>)\u2010infected pigs were compared. Tulathromycin was administered intramuscularly (i.m.) to all pigs at a single dose of 2.5\u00a0mg\/kg. Blood and lung tissue samples were collected during 33\u00a0days postdrug application. Tulathromycin concentration in plasma and lung was determined by high\u2010performance liquid chromatography with tandem mass spectrometry (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) method. The mean maximum plasma concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) in healthy pigs was 586\u00a0\u00b1\u00a071\u00a0ng\/mL, reached by 0.5\u00a0h, while the mean value for <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> of tulathromycin in infected pigs was 386\u00a0\u00b1\u00a097\u00a0ng\/mL after 0.5\u00a0h. The mean maximum tulathromycin concentration in lung of healthy group was calculated as 3412\u00a0\u00b1\u00a0748\u00a0ng\/g, detected at 12\u00a0h, while in pigs with <jats:italic>App,<\/jats:italic> the highest concentration in lung was 3337\u00a0\u00b1\u00a0937\u00a0ng\/g, determined at 48\u00a0h postdosing. The higher plasma and lung concentrations in pigs with no pulmonary inflammation were observed at the first time points sampling after tulathromycin administration, but slower elimination with elimination half\u2010life <jats:italic>t<\/jats:italic><jats:sub>1\/2el<\/jats:sub>\u00a0=\u00a0126\u00a0h in plasma and <jats:italic>t<\/jats:italic><jats:sub>1\/2el<\/jats:sub>\u00a0=\u00a0165\u00a0h in lung, as well as longer drug persistent in infected pigs, was found.<\/jats:p>","DOI":"10.1111\/jvp.12259","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T13:00:53Z","timestamp":1439470853000},"page":"176-182","source":"Crossref","is-referenced-by-count":15,"title":["The influence of <i>Actinobacillus pleuropneumoniae<\/i> infection on tulathromycin pharmacokinetics and lung tissue disposition in pigs"],"prefix":"10.1111","volume":"39","author":[{"given":"A.","family":"Gajda","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology National Veterinary Research Institute Pulawy Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bladek","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology National Veterinary Research Institute Pulawy Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jablonski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology National Veterinary Research Institute Pulawy Poland"},{"name":"Department of Swine Diseases National Veterinary Research Institute Pulawy Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Posyniak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology National Veterinary Research Institute Pulawy Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(98)90134-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(01)00410-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00586.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4AY01165A"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/514619"},{"key":"e_1_2_6_7_1","first-page":"129","article-title":"Rapid and prolonged distribution of tulathromycin into lung homogenate and pulmonary epithelial lining fluid of Holstein calves following a single subcutaneous administration of 2.5\u00a0mg\/kg body weight","volume":"8","author":"Cox S.R.","year":"2010","journal-title":"International Journal of Applied Research in Veterinary Medicine"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1988.tb00123.x"},{"key":"e_1_2_6_9_1","first-page":"83","article-title":"Tulathromycin: an overview of a new triamilide antibiotic for livestock respiratory disease","volume":"6","author":"Evans N.A.","year":"2005","journal-title":"Veterinary Therapeutics"},{"issue":"1","key":"e_1_2_6_10_1","first-page":"108","article-title":"Penetration of danofloxacin into the respiratory tract tissues and secretions in healthy and in Actinobacillus pleuropneumoniae infected pigs. 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