{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:43:04Z","timestamp":1780076584914,"version":"3.54.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S&V Technologies GmbH"},{"name":"Veterinary Division Acrivet"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Therapeutic soft contact lenses (<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>s) are frequently used to support or protect the cornea during healing. Our aim was to quantitatively evaluate the efficacy of topical medications in<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>\u2010fitted dogs and determine whether it is affected by the presence of<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>s. In<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>hase I, pupil diameter was measured in eyes treated with tropicamide and in eyes covered with<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>s and then treated with tropicamide, with 1\u2010week intervals between sessions. In Phase<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) was measured in uncovered and<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>\u2010covered eyes treated with latanoprost, with 1\u2010week intervals between sessions. Tropicamide caused significant mydriasis in both uncovered and<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>\u2010covered eyes (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.005). On the other hand, latanoprost caused a significant decrease in<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>when applied to uncovered eyes (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.002), but had no significant effect on<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>when applied to<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>\u2010covered eyes (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.7). As we used the same dogs and identical<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>s throughout the study, we conclude that the different outcomes of the two drugs are due to properties of the drugs themselves, or their formulations, affecting their interaction with the<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>s. The clinical efficacy of topical drugs applied to<jats:styled-content style=\"fixed-case\">TSCL<\/jats:styled-content>\u2010covered eyes may have to be determined for each drug and\/or formulation.<\/jats:p>","DOI":"10.1111\/jvp.12263","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T05:34:04Z","timestamp":1443418444000},"page":"138-143","source":"Crossref","is-referenced-by-count":5,"title":["Interaction with therapeutic soft contact lenses affects the intraocular efficacy of tropicamide and latanoprost in dogs"],"prefix":"10.1111","volume":"39","author":[{"given":"M.","family":"Hatzav","sequence":"first","affiliation":[{"name":"Koret School of Veterinary Medicine Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Bdolah\u2010Abram","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine Hebrew University of Jerusalem Rehovot 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