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Blood samples were collected serially over 24\u00a0h. Plasma concentrations of DPH were determined by high\u2010performance liquid chromatography, and noncompartmental pharmacokinetic analysis was performed with the commercially available software. Cardio\u2010respiratory parameters, rectal temperature and effects on behaviour, such as sedation or excitement, were recorded. Diphenhydramine Cl<jats:sub>area<\/jats:sub>, Vd<jats:sub>area<\/jats:sub>and<jats:italic>T<\/jats:italic><jats:sub>1\/2<\/jats:sub>were 20.7 \u00b1\u00a02.9\u00a0mL\/kg\/min, 7.6\u00a0\u00b1\u00a00.7\u00a0L\/kg and 4.2\u00a0\u00b1\u00a00.5\u00a0h for the i.v. route, respectively, and Cl<jats:sub>area<\/jats:sub>\/<jats:italic>F<\/jats:italic>, Vd<jats:sub>area<\/jats:sub>\/<jats:italic>F<\/jats:italic>and<jats:italic>T<\/jats:italic><jats:sub>1\/2<\/jats:sub>20.8\u00a0\u00b1\u00a02.7\u00a0mL\/kg\/min, 12.3\u00a0\u00b1\u00a01.2\u00a0L\/kg and 6.8\u00a0\u00b1\u00a00.7\u00a0h for the i.m. route, respectively. Bioavailability was 88% after i.m. administration. No significant differences were found in physiological parameters between groups or within dogs of the same group, and values remained within normal limits. No adverse effects or changes in mental status were observed after the administration of DPH. Both routes of administration resulted in DPH plasma concentrations which exceeded levels considered therapeutic in humans.<\/jats:p>","DOI":"10.1111\/jvp.12293","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T06:06:48Z","timestamp":1453874808000},"page":"452-459","source":"Crossref","is-referenced-by-count":8,"title":["The pharmacokinetics of DPH after the administration of a single intravenous or intramuscular dose in healthy dogs"],"prefix":"10.1111","volume":"39","author":[{"given":"A.","family":"Sanchez","sequence":"first","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Valverde","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mosley","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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