{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:10:04Z","timestamp":1788271804529,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,14]],"date-time":"2016-02-14T00:00:00Z","timestamp":1455408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Nonsteroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) are recommended for various conditions in cattle. Ibuprofen is an inexpensive short\u2010acting<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>and is readily available in liquid formulation for administration to bottle\u2010fed calves. We compared the adverse effects of a 10\u2010day course of ibuprofen and placebo in 16 five\u2010 to six\u2010week\u2010old Holstein bull calves that were being treated for experimentally induced bovine respiratory syncytial virus infection. Ibuprofen was administered as a liquid in milk replacer at 30\u00a0mg\/kg divided three times daily. We found an increased prevalence of abomasal ulceration 5 of 8 in the ibuprofen compared to placebo group 2 of 6 (<jats:italic>P\u00a0<\/jats:italic>=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). There was one (1 of 8) case of mild interstitial nephritis in the ibuprofen and none (0 of 8) in the placebo group (<jats:italic>P\u00a0<\/jats:italic>=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). Renal function as measured by serum<jats:styled-content style=\"fixed-case\">BUN<\/jats:styled-content>and creatinine levels was not different between groups; no animal demonstrated an increase in creatinine.<\/jats:p>","DOI":"10.1111\/jvp.12295","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T04:49:01Z","timestamp":1455511741000},"page":"518-521","source":"Crossref","is-referenced-by-count":10,"title":["Adverse effects of a 10\u2010day course of ibuprofen in<scp>H<\/scp>olstein calves"],"prefix":"10.1111","volume":"39","author":[{"given":"P.","family":"Walsh","sequence":"first","affiliation":[{"name":"Pediatric Emergency Medicine Sutter Medical Center Sacramento CA USA"},{"name":"Department of Emergency Medicine University of California Davis Sacramento CA USA"},{"name":"Department of Pathology, Microbiology, and Immunology School of Veterinary Medicine University of California Davis Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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