{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:39:32Z","timestamp":1783762772680,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T00:00:00Z","timestamp":1455926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007765","name":"Kansas State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>The purpose of this study was to determine the pharmacokinetic and antinociceptive effects of an acetaminophen\/codeine combination administered orally to six healthy greyhounds. Antinociception was assessed using an electronic von Frey (<jats:styled-content style=\"fixed-case\">vF<\/jats:styled-content>) device as a mechanical\/pressure model. Acetaminophen was administered at a dose of 600\u00a0mg (14.4\u201323.1\u00a0mg\/kg) and codeine phosphate at 90\u00a0mg (2.1\u20133.3\u00a0mg\/kg) equivalent to 67.5\u00a0mg codeine base (1.6\u20132.5\u00a0mg\/kg). The geometric mean maximum plasma concentrations of acetaminophen, codeine, and codeine\u20106\u2010glucuronide were 7.95\u00a0<jats:italic>\u03bc<\/jats:italic>g\/mL, 11.0\u00a0ng\/mL, and 3819\u00a0ng\/mL, respectively. Morphine concentrations were &lt;1\u00a0ng\/mL. The terminal half\u2010lives of acetaminophen, codeine, and codeine\u20106\u2010glucuronide were 0.94, 1.71, and 3.12\u00a0h. There were no significant changes in <jats:styled-content style=\"fixed-case\">vF<\/jats:styled-content> thresholds, except at 12\u00a0h which decreased on average by 17% compared to baseline. The decrease in <jats:styled-content style=\"fixed-case\">vF<\/jats:styled-content> thresholds at 12\u00a0h could be due to aversion, hyperalgesia, or random variability. The lack of antinociception in this study could be due to a true lack of antinociception, lack of model sensitivity, or specificity. Further studies using different models (including clinical trials), different dog breeds, multiple dose regimens, and a range of dosages are needed prior to recommended use or concluding lack of efficacy for oral acetaminophen\/codeine in dogs.<\/jats:p>","DOI":"10.1111\/jvp.12299","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T20:58:02Z","timestamp":1456001882000},"page":"514-517","source":"Crossref","is-referenced-by-count":27,"title":["Pharmacokinetics and pharmacodynamics of oral acetaminophen in combination with codeine in healthy Greyhound dogs"],"prefix":"10.1111","volume":"39","author":[{"given":"B.","family":"KuKanich","sequence":"first","affiliation":[{"name":"Department of Anatomy and Physiology College of Veterinary Medicine Kansas State University Manhattan KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,20]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510060407"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.76.9.763"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.05.019"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12140"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2009.01098.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2007.00369.x"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12257"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.2.256"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.09.008"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2005.00661.x"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.1616"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.1968"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2011.00602.x"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012748"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.12.307"},{"key":"e_1_2_3_17_1","first-page":"811","article-title":"Meperidine pharmacokinetics following intravenous, peroral and buccal administration in beagle dogs","volume":"9","author":"Ritschel W.A.","year":"1987","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(97)90103-8"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600680441"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12299","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T09:58:10Z","timestamp":1695031090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,20]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/jvp.12299"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12299","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,20]]}}}