{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:51:34Z","timestamp":1793479894049,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T00:00:00Z","timestamp":1465948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Searching for new therapeutic options against septic arthritis in horses, this research was focused on the study of the kinetics and local side effects after the intra\u2010articular treatment of horses with cefovecin sodium. A single dose (240\u00a0mg) of the drug (Convenia<jats:sup>\u00ae<\/jats:sup>) was administered into the radiocarpal joint of adult healthy horses (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), and drug concentrations in plasma and synovial fluid were determined by high\u2010performance liquid chromatography (<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>). Local tolerance was also studied based on the modification of different joint physiopathological parameters (<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>, cellular, and protein concentration in synovial fluid). Although no clinically relevant joint damage was noticed, significant increases in the protein concentrations at 5\u00a0min and in the cellular concentration at 30\u00a0min after cefovecin administration were observed in the treated radiocarpal joints. The duration of the cefovecin above the minimal inhibitory concentration (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>) \u22641\u00a0<jats:italic>\u03bc<\/jats:italic>g\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>was 28.80\u00a0\u00b1\u00a02.58\u00a0h in the radiocarpal joint and 16.00\u00a0\u00b1\u00a02.86\u00a0h in plasma. The results of this study showed that intra\u2010articular administration of cefovecin sodium in horses could be considered in the future to manage septic arthritis in horses, as it offers a good pharmacokinetic behavior and good local tolerance.<\/jats:p>","DOI":"10.1111\/jvp.12324","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T14:04:58Z","timestamp":1465999498000},"page":"28-34","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetics and local tolerance of cefovecin sodium after intra\u2010articular administration in horses"],"prefix":"10.1111","volume":"40","author":[{"given":"M.","family":"P\u00e9rez\u2010Nogu\u00e9s","sequence":"first","affiliation":[{"name":"Departament of Medicina y Cirug\u00eda Animal Facultad de Veterinaria Universidad Complutense de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Encinas","sequence":"additional","affiliation":[{"name":"Department of Toxicolog\u00eda y Farmacolog\u00eda Facultad de Veterinaria Universidad Complutense de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"L\u00f3pez\u2010SanRoman","sequence":"additional","affiliation":[{"name":"Departament of Medicina y Cirug\u00eda Animal Facultad de Veterinaria Universidad Complutense de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"140","article-title":"Limitations and uses of cefovecin in zoological practice","author":"Bertelsen M.F.","year":"2010","journal-title":"Proceedings of the International Conference on Diseases of Zoo and Wild Animals"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.1.15"},{"key":"e_1_2_7_4_1","first-page":"617","article-title":"Comparison of 2 techniques for regional antibiotic delivery to the equine forelimb: intraosseous perfusion vs. intravenous perfusion","volume":"42","author":"Butt T.D.","year":"2001","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_7_5_1","first-page":"210","article-title":"Septic arthritis in adult horses","volume":"13","author":"Carstanjen B.","year":"2010","journal-title":"Polish journal of veterinary sciences"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2460\/ajvr.1993.54.04.573","article-title":"Pharmacokinetics and concentrations of ceftiofur sodium in body fluids and endometrium after repeated intramuscular injections in mares","volume":"54","author":"Cervantes C.C.","year":"1993","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3129"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12181"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2007.00235.x"},{"key":"e_1_2_7_10_1","unstructured":"EMEA. EMEA\/CVMP\/215997\/2006.Convenia: Scientific discussion2006. Available at:http:\/\/www.ema.europa.eu(accessed December 15 2014)."},{"key":"e_1_2_7_11_1","first-page":"42","volume-title":"Proceedings of the IAAAM 41st Annual Conference","author":"Garc\u00eda\u2010P\u00e1rraga D.","year":"2010"},{"key":"e_1_2_7_12_1","first-page":"S55","article-title":"Pharmacokinetics of cefovecin in rabbits","volume":"66","author":"Gilabert J.A.","year":"2010","journal-title":"European journal of clinical pharmacology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.9.1519"},{"key":"e_1_2_7_14_1","volume-title":"Guide for Veterinary Services and Judging of Equestrian Events, 4th edition, Eds","author":"Kester W.O.","year":"1991"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1992.tb02872.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.683"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2460\/ajvr.1988.49.05.644","article-title":"Plasma and synovial fluid concentrations of gentamicin in horses after intra\u2010articular administration of buffered and unbuffered gentamicin","volume":"49","author":"Lloyd K.C.","year":"1988","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.2460\/ajvr.1990.51.09.1363","article-title":"Synovial fluid pH, cytologic characteristics, and gentamicin concentration after intra\u2010articular administration of the drug in an experimental model of infectious arthritis in horses","volume":"51","author":"Lloyd K.C.","year":"1990","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9846(17)30083-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2000.9141"},{"key":"e_1_2_7_21_1","first-page":"231","article-title":"Pharmacokinetics of cefovecin (Convenia\u2122) by subcutaneous route in ferrets (Mustela putorius furo)","author":"Montesinos A.","year":"2010","journal-title":"Proceedings of the International Conference on Diseases of Zoo and Wild Animals"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1992.tb02875.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.12.1949"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00596.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2005.00667.x"},{"key":"e_1_2_7_26_1","first-page":"805","article-title":"Pharmacokinetics of Cefovecin in Squirrel Monkey (Saimiri sciureus), Rhesus Macaques (Macaca mulatta), and Cynomolgus Macaques (Macaca\u00a0fascicularis)","volume":"49","author":"Papp R.","year":"2010","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2005.00095.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.10.1701"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1992.tb02873.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1996.tb00006.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00077-06"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2006.00801.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2006.00795.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2460\/ajvr.1985.46.12.2485","article-title":"Effects of intra\u2010articular gentamicin sulfate on normal equine synovial membrane","volume":"46","author":"Stover S.M.","year":"1985","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.02.009"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2009.01083.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2460\/ajvr.1982.43.04.594","article-title":"Effect of itra\u2010articular injection of orgotein and saline solution on equine synovia","volume":"43","author":"Wagner A.E.","year":"1982","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2010.10.002"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516403775467225"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12324","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T21:47:44Z","timestamp":1748987264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,15]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/jvp.12324"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12324","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,15]]}}}