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In each of two studies (studies 1 and 2), 32 beagle dogs were randomized into one of four groups in a parallel\u2010group design. Groups received once\u2010daily oral treatment for 7\u00a0days with placebo, benazepril, robenacoxib or benazepril plus robenacoxib. In study 2, all dogs received additionally 2\u00a0mg\/kg furosemide orally twice daily. The primary endpoint was the glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) estimated from the plasma clearance of iohexol. Secondary endpoints included standard clinical monitoring and, in study 2, plasma renin activity, urine volume, specific gravity and aldosterone concentration and water intake. Administration of furosemide induced diuresis, reduced<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>and activated the renin\u2013aldosterone\u2013angiotensin system. Benazepril and robenacoxib, administered alone or in combination, were tolerated well, did not decrease<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>with or without co\u2010administration of furosemide and significantly reduced urinary aldosterone concentrations. No increased risk of acute kidney injury was identified with the combination of benazepril and robenacoxib in healthy dogs. Different effects might occur in dogs with heart or renal disease.<\/jats:p>","DOI":"10.1111\/jvp.12325","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T17:22:07Z","timestamp":1466011327000},"page":"44-56","source":"Crossref","is-referenced-by-count":4,"title":["Effect of benazepril and robenacoxib and their combination on glomerular filtration rate in dogs"],"prefix":"10.1111","volume":"40","author":[{"given":"A.","family":"Panteri","sequence":"first","affiliation":[{"name":"Preclinical Elanco Centre de Recherche Sant\u00e9 Animale St\u2010Aubin Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kukk","sequence":"additional","affiliation":[{"name":"Preclinical Elanco Centre de Recherche Sant\u00e9 Animale St\u2010Aubin Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Desevaux","sequence":"additional","affiliation":[{"name":"Safety Elanco Animal Health Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Seewald","sequence":"additional","affiliation":[{"name":"Companion Animal Development Elanco Animal Health Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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