{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:00:02Z","timestamp":1793466002760,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004539","name":"Kasetsart University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>To evaluate the fate and disposition of marbofloxacin (<jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>) in freshwater crocodiles <jats:italic>(Crocodylus siamensis)<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> MBF<\/jats:styled-content> was administered either intravenously (i.v.) or intramuscularly (i.m.) at a dosage of 2.0\u00a0mg\/kg body weight. The concentrations of <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content> in plasma were measured using high\u2010performance liquid chromatography equipped with a fluorescence detector. The concentrations of <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content> in the plasma were measurable up to 144\u00a0h after i.v. and i.m. administration. After the first 45\u00a0min, the mean pharmacokinetic profiles produced by the two administration routes were almost identical. No statistically significant differences in the pharmacokinetic parameters between the groups were observed. The half\u2010life was long (about 2.5\u00a0days), the volume of distribution was large (about 1.44\u00a0L\/kg), <jats:italic>\u03bb<\/jats:italic>z was small (0.01 h<jats:sup>\u22121<\/jats:sup>), and the clearance was slow (22.6\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/h\/kg). The absolute i.m. bioavailability (F%) was 105.36%. The dose of <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content> administered in this study seems to produce appropriate <jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> parameters that predict antibacterial success for disease caused by susceptible bacteria. More studies are warranted to evaluate the likely residues after administration of multiple doses.<\/jats:p>","DOI":"10.1111\/jvp.12335","type":"journal-article","created":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T04:12:43Z","timestamp":1466223163000},"page":"57-61","source":"Crossref","is-referenced-by-count":20,"title":["Pharmacokinetics of marbofloxacin in freshwater crocodiles (<i>Crocodylus siamensis<\/i>) after intravenous and intramuscular administration"],"prefix":"10.1111","volume":"40","author":[{"given":"S.","family":"Poapolathep","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Pisa San Piero a Grado Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hantrakul","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Klangkaew","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sanyathitiseree","sequence":"additional","affiliation":[{"name":"Department of Large Animal and Wildlife Clinical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Poapolathep","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(00)00185-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2006.07.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1996.tb00001.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1638\/04-102.1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.3.483"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118675014.ch18"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1638\/03-001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.21.2.1334"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1638\/2008-0041.1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2007.00845.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2008.00956.x"},{"key":"e_1_2_6_13_1","unstructured":"Lai O. 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