{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:50:29Z","timestamp":1775742629318,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>The objective of this study was to compare active drug concentrations in the plasma vs. different effector compartments including interstitial fluid (<jats:styled-content style=\"fixed-case\">ISF<\/jats:styled-content>) and pulmonary epithelial lining fluid (<jats:styled-content style=\"fixed-case\">PELF<\/jats:styled-content>) of healthy preruminating (3\u2010week\u2010old) and ruminating (6\u2010month\u2010old) calves. Eight calves in each age group were given a single subcutaneous (s.c.) dose (8\u00a0mg\/kg) of danofloxacin. Plasma,<jats:styled-content style=\"fixed-case\">ISF<\/jats:styled-content>, and bronchoalveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>) fluid were collected over 96\u00a0h and analyzed by high\u2010pressure liquid chromatography.<jats:styled-content style=\"fixed-case\">PELF<\/jats:styled-content>concentrations were calculated by a urea dilution assay of the<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>fluids. Plasma protein binding was measured using a microcentrifugation system. For most preruminant and ruminant calves, the concentration\u2013time profile of the central compartment was best described by a two\u2010compartment open body model. For some calves, a third compartment was also observed. The time to maximum concentration in the plasma was longer in preruminating calves (3.1\u00a0h) vs. ruminating calves (1.4\u00a0h). Clearance (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\/F) was 385.15 and 535.11\u00a0mL\/h\/kg in preruminant and ruminant calves, respectively. Ruminant calves maintained higher<jats:styled-content style=\"fixed-case\">ISF<\/jats:styled-content>\/plasma concentration ratios throughout the study period compared to that observed in preruminant calves. Potential reasons for age\u2010related differences in plasma concentration\u2013time profiles and partitioning of the drug to lungs and<jats:styled-content style=\"fixed-case\">ISF<\/jats:styled-content>as a function of age are explored.<\/jats:p>","DOI":"10.1111\/jvp.12346","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T16:01:13Z","timestamp":1470153673000},"page":"179-191","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetics and distribution in interstitial and pulmonary epithelial lining fluid of danofloxacin in ruminant and preruminant calves"],"prefix":"10.1111","volume":"40","author":[{"given":"D. A.","family":"Mzyk","sequence":"first","affiliation":[{"name":"Department of Population Health and Pathobiology and the Food Animal Residue Avoidance Depletion Program College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Baynes","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology and the Food Animal Residue Avoidance Depletion Program College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-4482","authenticated-orcid":false,"given":"K. M.","family":"Messenger","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Martinez","sequence":"additional","affiliation":[{"name":"US Food and Drug Administration Center for Veterinary Medicine Office of New Animal Drug Evaluation Rockville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology and the Food Animal Residue Avoidance Depletion Program College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.10.2793-2797.2001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1665-1670.2002"},{"key":"e_1_2_8_4_1","first-page":"937","article-title":"Lung\u2010tissue concentrations and plasma pharmacokinetics of danofloxacin in calves with acute pneumonia","volume":"54","author":"Apley M.D.","year":"1993","journal-title":"Veterinary Sciences"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.6.1171"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2006.11.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-008-9053-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12267"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2005.00664.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1996.tb00005.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090510"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9811049"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.2.310"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2007.00914.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.5.528"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)00008-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt197517144"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149100"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.2460\/ajvr.1993.54.07.1122","article-title":"Penetration of danofloxacin into the respiratory tract tissues and secretions in calves","volume":"54","author":"Friis C.","year":"1993","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.3505"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.3.326"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1991.tb00854.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00092-12"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038030-00005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197609022951006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1997.00100.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035092"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00133-06"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(02)00025-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2356-2361.2005"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12104"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.8.1988"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2011.01349.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2011.01338.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2011.01331.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm476"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1983.tb00455.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.2460\/ajvr.1986.47.03.642","article-title":"Age and dosage dependency in the plasma disposition and the renal clearance of sulfamethazine and its N4 \u2013 acetyl and hydroxyl metabolites in calves and cows","volume":"4","author":"Nouws J.","year":"1986","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_8_40_1","unstructured":"Pfizer Inc(1989a).Nonclinical Total Residue Excretion Study in Cattle. Unpublished Study No. 1535N\u201060\u201088\u2010008 from Pfizer Central Research Terre Haute IN and Groton CT. Supplement to the Total Residue Excretion Study in Cattle Experiment No. 1535N\u201060\u201088\u2010008. Unpublished Study from Pfizer Central Research Groton CT."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2008.10.007"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.12.001"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1980.tb00413.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-009-9215-6"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.9.3013-3019.2002"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(03)00005-5"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.342"},{"key":"e_1_2_8_48_1","first-page":"342","article-title":"Rational dosing of antimicrobial agents for bovine respiratory disease: the use of plasma versus tissue concentrations in predicting efficacy","volume":"9","author":"Tessman R.K.","year":"2011","journal-title":"The Journal of Applied Research in Veterinary Medicine"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1515\/acve-2015-0022"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2002.00442.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00600.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1990.9694251"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2014.10.012"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.02.010"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:22:09Z","timestamp":1749036129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,31]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jvp.12346"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12346","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,31]]}}}