{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:13:40Z","timestamp":1776226420389,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T00:00:00Z","timestamp":1470355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>The objective of the study was to establish the dose\u2013response relationship for robenacoxib, a selective cyclooxygenase (<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>)\u20102 inhibitor, in a urate crystal model of acute synovitis. In a randomized partial Latin square design trial, 12 beagle dogs were administered orally single doses of robenacoxib (0.5, 1, 2, 4 and 8\u00a0mg\/kg), placebo and the positive control meloxicam (0.1\u00a0mg\/kg), 3\u00a0h after injection of sodium urate crystals into a stifle joint. Dogs were assessed for weight bearing on a force plate and by subjective clinical orthopaedic observations. Robenacoxib produced dose\u2010dependent improvement in weight bearing, and decreased pain on palpation and joint swelling, over the dose range 0.5\u20132\u00a0mg\/kg with no further increase in effect over the range 2\u20138\u00a0mg\/kg. For weight bearing on the force plate, the<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content><jats:sub>50<\/jats:sub>of robenacoxib was 0.6\u20130.8\u00a0mg\/kg. The onset of action and time to peak effect of robenacoxib were faster (respectively, 2\u20132.5\u00a0h and 3\u20135\u00a0h) than for meloxicam (respectively, 3\u00a0h and 6\u00a0h). Robenacoxib significantly inhibited<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 at all doses, with dose\u2010related activity. Robenacoxib did not inhibit<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20101 over the dose range 0.5\u20134\u00a0mg\/kg, but produced transient inhibition at 8\u00a0mg\/kg. In conclusion, oral administration of robenacoxib over the dose range 0.5\u20138\u00a0mg\/kg demonstrated significant analgesic and anti\u2010inflammatory efficacy in dogs.<\/jats:p>","DOI":"10.1111\/jvp.12348","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T05:16:04Z","timestamp":1470374164000},"page":"148-157","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of the dose\u2013response relationship of oral robenacoxib in urate crystal\u2010induced acute stifle synovitis in dogs"],"prefix":"10.1111","volume":"40","author":[{"given":"L.R.","family":"Borer","sequence":"first","affiliation":[{"name":"Elanco Animal Health Research Centre St\u2010Aubin Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Seewald","sequence":"additional","affiliation":[{"name":"Elanco Animal Health Inc. 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