{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:59:20Z","timestamp":1775019560044,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ID 31372486"],"award-info":[{"award-number":["ID 31372486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>The aim of the study was to develop praziquantel (<jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content>) oily suspensions with 30% <jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content> high concentration for intramuscular injection and investigate their pharmacokinetics in cattle. Two optimized formulations containing 30% <jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content> were developed in this study, and their quality met the technical standards set by the Ministry of Agriculture of the People's Republic of China. After intramuscular administrations of the suspensions (30\u00a0mg\/kg), no significant differences were observed between the two oily suspensions. However, compared with the market available <jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content> tablet after oral administration (150\u00a0mg\/kg), our injections revealed longer plasma elimination half\u2010life (26.23, 22.16\u00a0h vs 6.35\u00a0h) and mean residence time (27.10, 25.88\u00a0h vs 9.16\u00a0h), indicating the antiparasitic efficacy of our suspensions may be prolonged, and further clinical efficacy investigation is needed. In addition, the relative bioavailability of our formulated suspensions was improved up to 441.32% and 425.60% compared with the oral reference product. Therefore, the injectable suspensions have the potential to become antiparasitic agents for the treatment of cattle schistosomiasis.<\/jats:p>","DOI":"10.1111\/jvp.12378","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T06:05:38Z","timestamp":1480572338000},"page":"454-458","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacokinetics of new high\u2010concentration and long\u2010acting praziquantel oily suspensions after intramuscular administration in cattle"],"prefix":"10.1111","volume":"40","author":[{"given":"M.","family":"Qian","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine China Agricultural University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine China Agricultural University Beijing China"},{"name":"Beijing Animal Health Inspection Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hao","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine China Agricultural University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"612","article-title":"Pharmacokinetics and bioavailability of praziquantel in cattle after oral, intramuscular and intravenous administration","volume":"21","author":"Cao J.","year":"2001","journal-title":"Chinese Journal of Veterinary Science"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2004.01.002"},{"key":"e_1_2_7_4_1","first-page":"6","volume-title":"Appendix\u00a0of Chinese Veterinary Pharmacopoeia","author":"Commission of Chinese Veterinary Pharmacopoeia (CCVP)","year":"2010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00031-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(97)01057-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2001.00341.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389899"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00075-8"},{"key":"e_1_2_7_10_1","first-page":"84","article-title":"Pharmacokinetics study of praziquantel after oral administration in cashmere goat","volume":"23","author":"Jia D.","year":"2001","journal-title":"Journal of Jilin Agricultural University"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-4-290"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(96)01092-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2003.12.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.04.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2011.01364.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.10.021"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2016.01.024"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389898"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2009.06.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-5-275"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12378","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:50:37Z","timestamp":1696150237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/jvp.12378"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12378","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}