{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:24:33Z","timestamp":1792787073917,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T00:00:00Z","timestamp":1493424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Winifred Violet Scott Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n                    The pharmacokinetic profile of posaconazole in clinically normal koalas (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08) was investigated. Single doses of posaconazole were administered intravenously (i.v.; 3\u00a0mg\/kg;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a02) or orally (p.o.; 6\u00a0mg\/kg;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06) with serial plasma samples collected over 24 and 36\u00a0hr, respectively. Plasma concentrations of posaconazole were quantified by validated high\u2010performance liquid chromatography. A noncompartmental pharmacokinetic analysis of data was performed. Following i.v. administration, estimates of the median (range) of plasma clearance (\n                    <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                    ) and steady\u2010state volume of distribution (\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>ss<\/jats:sub>\n                    ) were 0.15 (0.13\u20130.18) L\u00a0hr\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 1.23 (0.93\u20131.53) L\/kg, respectively. The median (range) elimination half\u2010life (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    ) after i.v. and p.o. administration was 7.90 (7.62\u20138.18) and 12.79 (11.22\u201316.24) hr, respectively. Oral bioavailability varied from 0.43 to 0.99 (median: 0.66). Following oral administration, maximum plasma concentration (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    ; median: 0.72, range: 0.55\u20130.93\u00a0\u03bcg\/ml) was achieved in 8 (range 6\u201312) hr. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    plasma protein binding of posaconazole incubated at 37\u00b0C was 99.25\u00a0\u00b1\u00a00.29%. Consideration of posaconazole pharmacokinetic\/pharmacodynamic (\n                    <jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    ) targets for some yeasts such as disseminated candidiasis suggests that posaconazole could be an efficacious treatment for cryptococcosis in koalas.\n                  <\/jats:p>","DOI":"10.1111\/jvp.12407","type":"journal-article","created":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T13:30:25Z","timestamp":1493472625000},"page":"675-681","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacokinetics of posaconazole in koalas (\n                    <i>Phascolarctos cinereus<\/i>\n                    ) after intravenous and oral administration"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5758-5308","authenticated-orcid":false,"given":"S.","family":"Gharibi","sequence":"first","affiliation":[{"name":"Sydney School of Veterinary Science The University of Sydney Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kimble","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science The University of Sydney Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Vogelnest","sequence":"additional","affiliation":[{"name":"Taronga Zoo Mosman NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Santa Barbara Zoo Santa Barbara CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Stadler","sequence":"additional","affiliation":[{"name":"Los Angeles Zoo Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Govendir","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science The University of Sydney Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt508"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12072"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.Supplement_3.S318"},{"key":"e_1_2_6_5_1","first-page":"576","article-title":"Pharmacokinetics of meloxicam in animals and the relevance to humans","volume":"26","author":"Busch U.","year":"1998","journal-title":"Drug Metabolism and Disposition"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00637-11"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit358"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00126-13"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00663-08"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2016.01.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689622"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13795"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.9.2788-2795.2003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01977.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05900-11"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01115-12"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.519349"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01407-09"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12285"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01295.x"},{"key":"e_1_2_6_21_1","unstructured":"International Conference on Harmonisation(2005).ICH Harmonised tripartite guideline: validation of analytical procedures: text and methodology Q2(R1). Geneva Switzerland. Retrieved fromhttp:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Quality\/Q2_R1\/Step4\/Q2_R1__Guideline.pdf"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.76.5.454"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.594967"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12038"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01074-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3543-3551.2004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01034-08"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.40.3.263.272"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/369378031000137242"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.01.006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000399603.91138.e7"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2165\/11319340-000000000-00000"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01671-10"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14523"},{"key":"e_1_2_6_35_1","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/AAC.40.8.1910","article-title":"In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans","volume":"40","author":"Perfect J. R.","year":"1996","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00308-13"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00163-06"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01216-08"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm328"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1086\/508774"},{"key":"e_1_2_6_42_1","unstructured":"Woods R. &Blyde D.(1997).Cryptic nasal disease revealed The Veterinarian p.6."},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1638\/2012-0045R.1"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.01.007"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:50:00Z","timestamp":1695948600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,29]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/jvp.12407"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12407","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,29]]}}}