{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:22:53Z","timestamp":1750220573713,"version":"3.41.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dynabyte (former manufacturer of the Multiplate Analyzer)","award":["Dynabyte provided free of charge material for the testing of platelet function with the Multiplate Analyzer"],"award-info":[{"award-number":["Dynabyte provided free of charge material for the testing of platelet function with the Multiplate Analyzer"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>The reasons for this prospective experimental study were to determine a dosing scheme with loading and maintenance dose of aspirin inducing inhibition of platelet function measured by whole blood impedance aggregometry. Ten horses received aspirin orally in the morning with one loading dose of 4.7\u20135\u00a0mg\/kg and maintenance doses of 1\u20131.3\u00a0mg\/kg daily the following 4\u00a0days. Aggregometries (<jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>test,<jats:styled-content style=\"fixed-case\">ASPI<\/jats:styled-content>test,<jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>test) and serum salicylic acid were measured.<jats:styled-content style=\"fixed-case\">ASPI<\/jats:styled-content>test showed significant difference in inhibition at 24 and 48\u00a0hr (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and 96\u00a0hr (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). Significant change for<jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>test and<jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>test couldn't be detected. Serum salicylic acid concentrations were significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) increased at 6 and 12\u00a0hr. Despite this, three horses failed any inhibitory effect of platelet function, suspecting an aspirin resistance. Regarding the other seven horses platelet aggregation induced by<jats:styled-content style=\"fixed-case\">ASPI<\/jats:styled-content>test was reduced between 37% and 100% from baseline at 6 and 12\u00a0hr and between 0 and 98% during the next 4\u00a0days. Correlations of serum concentration of salicylic acid and aggregometries couldn't be detected. It can be presumed that equine platelets are less susceptible to aspirin what may compromise eventually the anticoagulatory effects and efficacy in preventing and treating diseases with increased platelet activation as endotoxaemia or laminitis.<\/jats:p>","DOI":"10.1111\/jvp.12408","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T04:26:43Z","timestamp":1491625603000},"source":"Crossref","is-referenced-by-count":4,"title":["Suspected aspirin resistance in individual healthy adult warmblood horses"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3810-8004","authenticated-orcid":false,"given":"K. 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