{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:47:22Z","timestamp":1761648442371,"version":"3.41.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Cardiopulmonary and sedative effects of intravenous or epidural methadone\u00a0were compared. Six beagles were randomly assigned to group<jats:styled-content style=\"fixed-case\">MIV<\/jats:styled-content>(methadone 0.5\u00a0mg\/kg<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>+ NaCl 0.9% epidurally) or<jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content>(methadone 0.5\u00a0mg\/kg epidurally + NaCl 0.9%<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>). Cardiopulmonary, blood gas and sedation were assessed at time (T) 0, 15, 30, 60, 120, 240 and 480\u00a0min after drug administration. Compared to T0, heart rate decreased at T15\u2013T120 in<jats:styled-content style=\"fixed-case\">MIV<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) and T15\u2013T240 in\u00a0<jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05); mean arterial pressure was reduced at T15\u2013T60 in<jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01); respiratory rate was higher at T15 and T30 in both groups (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05);<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>was lower at T15\u2013T120 in<jats:styled-content style=\"fixed-case\">MIV<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01) and\u00a0T15, T30 and T120 in<jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05); Pa<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub>was higher at T15\u2013T60 in<jats:styled-content style=\"fixed-case\">MIV<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01) and T15, T30 and T120 in<jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01); sedation scores were higher at T15 and T30 in<jats:styled-content style=\"fixed-case\">MIV<\/jats:styled-content>and T15\u2013T60 in<jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05). At T120 and T240, sedation score was higher in group<jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content>compared with group<jats:styled-content style=\"fixed-case\">MIV<\/jats:styled-content>(<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01) In conclusion, cardiopulmonary and sedative effects of identical methadone doses are similar when administered<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>or epidurally to conscious healthy\u00a0dogs.<\/jats:p>","DOI":"10.1111\/jvp.12416","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T05:02:48Z","timestamp":1494824568000},"source":"Crossref","is-referenced-by-count":4,"title":["Cardiopulmonary and sedative effects of intravenous or epidural methadone in conscious dogs"],"prefix":"10.1111","volume":"40","author":[{"given":"B. H. B.","family":"Vieira","sequence":"first","affiliation":[{"name":"Veterinary Science Graduate Program University of Franca Franca SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. T.","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Veterinary Science Graduate Program University of Franca Franca SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. L.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Veterinary Science Graduate Program University of Franca Franca SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Auckburally","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-5447","authenticated-orcid":false,"given":"E.","family":"Mattos\u2010Junior","sequence":"additional","affiliation":[{"name":"Veterinary Science Graduate Program University of Franca Franca SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1984.tb09459.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.08.019"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200000180"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.03.019"},{"key":"e_1_2_2_6_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0022-3565(25)23653-9","article-title":"Plasma arginine vasopressin response to intravenous methadone and naloxone in conscious dogs","volume":"248","author":"Hellebrekers L. 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