{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:48:09Z","timestamp":1784994489548,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm & Therapeutics"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Population pharmacokinetic of marbofloxacin was investigated with 52 plasma concentration\u2013time profiles obtained after intramuscular administration of Forcyl\u00ae in cattle. Animal's status, pre\u2010ruminant, ruminant, or dairy cow, was retained as a relevant covariate for clearance. Monte Carlo simulations were performed using a stratification by status, and 1000 virtual disposition curves were generated in each bovine subpopulation for the recommended dosage regimen of 10\u00a0mg\/kg as a single injection. The probability of target attainment (PTA<\/jats:styled-content>) of pharmacokinetic\/pharmacodynamic (PK<\/jats:styled-content>\/PD<\/jats:styled-content>) ratios associated with clinical efficacy and prevention of resistance was determined in each simulated subpopulation. The cumulative fraction of response (CFR<\/jats:styled-content>) of animals achieving a PK<\/jats:styled-content>\/PD<\/jats:styled-content> ratio predictive of positive clinical outcome was then calculated for the simulated dosage regimen, taking into account the minimum inhibitory concentration (MIC<\/jats:styled-content>) distribution of Pasteurella multocida<\/jats:italic>, Mannheimia haemolytica,<\/jats:italic> and Histophilus somni<\/jats:italic>. When considering a ratio of AUC<\/jats:styled-content>0\u201024\u00a0hr<\/jats:sub>\/MIC<\/jats:styled-content> (area under the curve\/minimum inhibitory concentration) greater than 125\u00a0hr, CFR<\/jats:styled-content>s ranging from 85% to 100% against the three Pasteurellaceae<\/jats:italic> in each bovine subpopulation were achieved. The PTA<\/jats:styled-content> of the PK<\/jats:styled-content>\/PD<\/jats:styled-content> threshold reflecting the prevention of resistances was greater than 90% up to MPC<\/jats:styled-content> (mutant prevention concentration) values of 1\u00a0\u03bcg\/ml in pre\u2010ruminants and ruminants and 0.5\u00a0\u03bcg\/ml in dairy cows.<\/jats:p>","DOI":"10.1111\/jvp.12418","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:03:07Z","timestamp":1495573387000},"page":"39-50","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacokinetic\/pharmacodynamic evaluation of marbofloxacin as a single injection for Pasteurellaceae<\/i> respiratory infections in cattle using population pharmacokinetics and Monte Carlo simulations"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-8825","authenticated-orcid":false,"given":"A.","family":"Paulin","sequence":"first","affiliation":[{"name":"Global Drug Development Division V\u00e9toquinol Lure Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Global Drug Development Division V\u00e9toquinol Lure Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Dron","sequence":"additional","affiliation":[{"name":"Global Drug Development Division V\u00e9toquinol Lure Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Woehrle","sequence":"additional","affiliation":[{"name":"Global Drug Development Division V\u00e9toquinol Lure Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2002.00399.x"},{"key":"e_1_2_8_3_1","first-page":"503","article-title":"Evaluation of enrofloxacin use in koalas (Phascolarctos cinereus) via population pharmacokinetics and Monte Carlo simulation","volume":"27","author":"Black L. A.","year":"2014","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"e_1_2_8_4_1","unstructured":"Clinical and Laboratory Standards Institute (CLSI). (2008).Performance Standards For Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals; Approved Standards. 3rdEdn. CLSI Document M31\u2010A3."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.01.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.5.1073"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm536"},{"key":"e_1_2_8_8_1","first-page":"287","article-title":"Efficacy of a single injection of marbofloxacin in the treatment of bovine respiratory disease","volume":"163","author":"Grandemange E.","year":"2012","journal-title":"Revue de M\u00e9decine V\u00e9t\u00e9rinaire"},{"key":"e_1_2_8_9_1","first-page":"199","article-title":"Single injection short acting antibiotic [SISAAB] for the treatment of acute coliform mastitis","volume":"20","author":"Grandemange E.","year":"2012","journal-title":"Cattle Practice"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2012.12.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2006.10.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.100246"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00603.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.14"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki079"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jvp.12346","article-title":"Pharmacokinetics and distribution in interstitial and pulmonary epithelial lining fluid of danofloxacin in ruminant and preruminant calves","volume":"40","author":"Mzyk D. A.","year":"2016","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005769"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.75.2.124"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq449"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/314059"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12125"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1095-3"},{"key":"e_1_2_8_23_1","unstructured":"Thomas V. Deleforge J. &Boiram\u00e9 B. (1994).Pharmacokinetic of marbofloxacin in pre\u2010ruminant and ruminant cattle. Proceedings of the 6thEAVPT international Congress Edinburgh UK 7\u201011 August P37 60\u201361."},{"key":"e_1_2_8_24_1","unstructured":"Thomas V. Deleforge J. Boiram\u00e9 B. &Espinasse J.(1994).Pharmacokinetic of marbofloxacin in healthy and sick pre\u2010ruminant calves. Proceedings of the 6thEAVPT international Congress Edinburgh UK 7\u201011 August P38 61."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm360"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(02)00039-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00047-06"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2011.01350.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12134"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12199"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.10.4009-4014.2005"},{"key":"e_1_2_8_32_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/jac\/dkn229","article-title":"A unified anti\u2010mutant dosing strategy","volume":"62","author":"Zhao X.","year":"2008","journal-title":"Antimicrobial Agents and Chemotherapy"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T21:52:55Z","timestamp":1695937975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,19]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/jvp.12418"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12418","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,19]]}}}