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The koala, a specialist folivore whose natural diet consists of almost exclusively<jats:italic>Eucalyptus<\/jats:italic>spp. foliage has anatomical and physiological adaptations for detoxifying their diet which also affect medicine pharmacokinetic profiles. This review addresses aspects of medicine absorption, clearance, and other indices (such as medicine binding to plasma proteins) of enrofloxacin\/marbofloxacin and chloramphenicol used for the systemic treatment of chlamydiosis, and fluconazole\u00a0\u00b1\u00a0amphotericin, and posaconazole for the treatment of cryptococcosis. 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