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This study compared the responsiveness of isolated bovine (<jats:styled-content style=\"fixed-case\">BDA<\/jats:styled-content>) and equine (<jats:styled-content style=\"fixed-case\">EDA<\/jats:styled-content>) digital arteries to pharmacological agents that stimulate receptor systems involved in the regulation of normal vessel tone. The role of the endothelium and the short\u2010 and longer\u2010term effects of an experimentally induced endothelial damage were also evaluated. Species\u2010related differences were found in the vessel reactivity to all of the receptor agonists tested. In intact<jats:styled-content style=\"fixed-case\">BDA<\/jats:styled-content>, as compared to intact<jats:styled-content style=\"fixed-case\">EDA<\/jats:styled-content>, norepinephrine was a more effective vasoconstrictor, 5\u2010hydroxytryptamine a more effective but less potent vasoconstrictor, isoproterenol a less effective vasodilator and carbamylcholine a less potent vasodilator. In<jats:styled-content style=\"fixed-case\">BDA<\/jats:styled-content>, but not in<jats:styled-content style=\"fixed-case\">EDA<\/jats:styled-content>, the contractile responses to norepinephrine and 5\u2010hydroxytryptamine were enhanced immediately after endothelium removal. However, the contractile reactivity of denuded<jats:styled-content style=\"fixed-case\">BDA<\/jats:styled-content>returned to basal values following overnight incubation. The differences suggest species specificity for the pathophysiology of digital vasomotor tone and function in horses and cattle.<\/jats:p>","DOI":"10.1111\/jvp.12436","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T12:52:50Z","timestamp":1499950370000},"page":"51-59","source":"Crossref","is-referenced-by-count":2,"title":["A comparative study between responses of isolated bovine and equine digital arteries to vasoactive mediators"],"prefix":"10.1111","volume":"41","author":[{"given":"C.","family":"Zizzadoro","sequence":"first","affiliation":[{"name":"Division of Veterinary Pharmacology and Toxicology Department of Veterinary Medicine University of Bari Valenzano Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Caruso","sequence":"additional","affiliation":[{"name":"Division of Veterinary Pharmacology and Toxicology Department of Veterinary Medicine University of Bari Valenzano Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Punzi","sequence":"additional","affiliation":[{"name":"Division of Veterinary Pharmacology and Toxicology Department of Veterinary Medicine University of Bari Valenzano Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Crescenzo","sequence":"additional","affiliation":[{"name":"Division of Veterinary Pharmacology and Toxicology Department of Veterinary Medicine University of Bari Valenzano Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zongoli","sequence":"additional","affiliation":[{"name":"Freelance Veterinarian Piacenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Belloli","sequence":"additional","affiliation":[{"name":"Division of Veterinary Pharmacology and Toxicology Department of Veterinary Medicine University of Bari Valenzano Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.2460\/ajvr.2000.61.862"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.2460\/ajvr.1990.51.12.1930","article-title":"Evaluation of equine digital Starling forces and hemodynamics during early laminitis","volume":"51","author":"Allen D.","year":"1990","journal-title":"American Journal of Veterinary Research"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/j.vetimm.2008.11.009"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1111\/j.2042-3306.1998.tb04471.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1016\/S0014-2999(98)00520-2"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1016\/S1090-0233(03)00120-5"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1111\/j.1532-950X.1995.tb01301.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2460\/ajvr.1989.50.04.508","article-title":"In vitro reactivity of digital arteries and veins to vasoconstrictive mediators in healthy horses and horses with early laminitis","volume":"50","author":"Baxter G. 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