{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:12:59Z","timestamp":1768461179199,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>A recrystallized form of enrofloxacin as dehydrate\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l (enro\u2010C) was assessed for bacteriological and clinical cure efficacies in Holstein\u2010Friesian cows affected of nonsevere clinical mastitis. Treatments were enro\u2010C<jats:sub>susp<\/jats:sub> (<jats:italic>n<\/jats:italic>\u00a0=\u00a081), treated with a pharmaceutical suspension of enro\u2010C\/quarter; group enro\u2010C<jats:sub>pd<\/jats:sub> (<jats:italic>n<\/jats:italic>\u00a0=\u00a080) treated as above, but using enro\u2010C powder suspended in water; group <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a065), treated with ceftiofur <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l\/quarter; and group enro<jats:sub>R<\/jats:sub> (<jats:italic>n<\/jats:italic>\u00a0=\u00a066), treated with standard enrofloxacin solution (5\u00a0mg\/kg, intramuscular). Cows had a mean milk production of 31\u00a0L\/day and were 2\u20103 lactational periods old. Treatments were administered every 24\u00a0hr for 3\u00a0days. Groups treated with enro\u2010C exhibited statistically significant (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05) better clinical cure as compared to groups treated with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> or enro<jats:sub>R<\/jats:sub> (95.06%, 96.25%, 67.79%, and 57.55%, for enro\u2010C<jats:sub>susp<\/jats:sub>, enro\u2010C<jats:sub>pd<\/jats:sub>, <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>, and enro<jats:sub>R<\/jats:sub>, respectively). In contrast, probability of bacteriological cure was not statistically different among treatments. Yet, the outstanding clinical and bacteriological cure rates obtained for enro\u2010C for nonsevere cases of mastitis is superior to previously reported data for parenteral enrofloxacin and other antibacterial\u2010intramammary treatments. Impact of using enro\u2010C on the rate and pattern of bacterial resistance, somatic cell counts and milk electric conductivity, must be studied. Also, the use of enro\u2010C for complicated cases of mastitis should be studied and milk withdrawal times must be accurately established.<\/jats:p>","DOI":"10.1111\/jvp.12441","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T12:04:37Z","timestamp":1501243477000},"source":"Crossref","is-referenced-by-count":9,"title":["Efficacy assessment of an intramammary treatment with a new recrystallized enrofloxacin vs ceftiofur and parenteral enrofloxacin in dairy cows with nonsevere clinical mastitis"],"prefix":"10.1111","volume":"41","author":[{"given":"M.","family":"Viveros","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology National Autonomous University of Mexico (UNAM)  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lopez\u2010Ordaz","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Animal Production Autonomous Metropolitan University  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology National Autonomous University of Mexico (UNAM)  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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