{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:12:11Z","timestamp":1775765531491,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["3202"],"award-info":[{"award-number":["3202"]}]},{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["UDP-45767"],"award-info":[{"award-number":["UDP-45767"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>This study was conducted to compare the pharmacokinetic profiles of conventional (Fungizone<jats:sup>\u00ae<\/jats:sup>) and liposomal amphotericin B (AmBisome<jats:sup>\u00ae<\/jats:sup>) formulations in order to predict their therapeutic properties, and evaluate their potential differences in veterinary treatment. For this purpose, twelve healthy mixed breed dogs received both drugs at a dose of 0.6\u00a0mg\/kg by intravenous infusion over a 4\u2010min period in a total volume of 40\u00a0ml. Blood samples were collected at 0, 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24, 48, 72 and 96\u00a0hr after dosing, and concentrations of drug in plasma were determined by high\u2010performance liquid chromatography (<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>). Pharmacokinetics was described by a two\u2010compartment model. Although both formulations were administered at the same doses (0.6\u00a0mg\/kg), the plasma pharmacokinetics of liposomal amphotericin B differed significantly from those of amphotericin B deoxycholate in healthy dogs (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Liposomal amphotericin B showed markedly higher peak plasma concentrations (approximately ninefold greater) and higher area under the plasma concentration curve values (approximately 14\u2010fold higher) compared to conventional formulation. It is concluded that AmBisome<jats:sup>\u00ae<\/jats:sup> reached higher plasma concentration and lower distribution volume and had a longer half\u2010life compared to Fungizone<jats:sup>\u00ae<\/jats:sup>, and therefore, AmBisome<jats:sup>\u00ae<\/jats:sup> is reported to be an appropriate and effective choice for the treatment of systemic mycotic infections in dogs.<\/jats:p>","DOI":"10.1111\/jvp.12446","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T08:12:29Z","timestamp":1502957549000},"source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the pharmacokinetic profiles of two different amphotericin B formulations in healthy dogs"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-7990","authenticated-orcid":false,"given":"B.","family":"Bing\u00f6l","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bakirel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv111"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics6010137"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2006.06.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-0481-67-17"},{"key":"e_1_2_6_6_1","first-page":"275","article-title":"Liposomal formulations of amphotericin B: Differences according to the scientific evidence","volume":"28","author":"Azanzo J. 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