{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:55:23Z","timestamp":1763747723954,"version":"3.41.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>The safety of synthetic levothyroxine sodium tablets (Thyro\u2010Tabs\u00ae Canine;<jats:styled-content style=\"fixed-case\">LLOYD<\/jats:styled-content>, Inc.) in dogs was evaluated in a randomized, sham\u2010dose controlled, parallel\u2010group study. Young, healthy, euthyroid Beagle dogs were randomized into four groups (four females and four males per group) and received single daily doses of 0\u00d7, 2\u00d7 (0.044\u00a0mg\/kg), 6\u00d7 (0.132\u00a0mg\/kg), or 10\u00d7 (0.22\u00a0mg\/kg) the labeled starting dose of 0.022\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>for 182\u00a0days. Every 2\u00a0weeks, physical examinations, electrocardiology examinations, and sample collections for thyroid panel, hematology, serum biochemistry, coagulation panel, and urinalysis were performed. At the end of the study, the dogs were euthanized and full necropsies performed. The most overt finding was the expected dose\u2010dependent increase in serum concentrations of total and free thyroxine with dose\u2010dependent suppression of the hypothalamic\u2013pituitary\u2013thyroid axis as evidenced by decreased serum thyroid\u2010stimulating hormone concentrations, decreased thyroid+parathyroid\/body weight ratios, and a trend for decreased pituitary weight\/brain weight ratios. Clinical signs of thyrotoxicosis (excitation, tachypnea, tachycardia) in the treated dogs were sporadic with no dose\u2013response relationship. Other findings statistically associated with levothyroxine treatment were generally mild and not clinically important. In summary, doses of levothyroxine sodium up to 10\u00d7 the labeled starting dose were well tolerated in healthy dogs.<\/jats:p>","DOI":"10.1111\/jvp.12457","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T06:06:39Z","timestamp":1510725999000},"page":"254-265","source":"Crossref","is-referenced-by-count":1,"title":["Safety of orally administered,<scp>USP<\/scp>\u2010compliant levothyroxine sodium tablets in dogs"],"prefix":"10.1111","volume":"41","author":[{"given":"J. E.","family":"Hare","sequence":"first","affiliation":[{"name":"Kingfisher International Stouffville Ontario Canada"},{"name":"Telemark Veterinary Consulting Inc. Port Perry Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-5041","authenticated-orcid":false,"given":"C. M. K.","family":"Morrow","sequence":"additional","affiliation":[{"name":"LLOYD, Inc. 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