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The objective of this study was to evaluate the safety of daily oral administration of capromorelin to cats over a range of doses and for an extended period. Two randomized, controlled studies were conducted: in Study 1, cats (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>6 per group) received placebo or capromorelin at a dose of 9, 15, 30 or 60\u00a0mg\/kg once daily for 14\u00a0days; and in Study 2, cats received capromorelin at 6\u00a0mg\/kg (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>8) or placebo (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4) once daily for 91\u00a0days. Cats were evaluated using clinical observations and clinical pathology test results for both studies, with the addition of postmortem examination in Study 1 and measurements of growth hormone and insulin\u2010like growth factor 1 in Study 2. Abnormal clinical observations were limited to emesis, hypersalivation, lethargy\/depression, head shaking and lip smacking, which occurred more frequently in the capromorelin\u2010treated groups than in the placebo group. There were no clinically relevant differences in clinical pathology test results between the capromorelin and placebo groups in either study.<\/jats:p>","DOI":"10.1111\/jvp.12459","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T04:06:45Z","timestamp":1508731605000},"page":"324-333","source":"Crossref","is-referenced-by-count":28,"title":["Evaluation of the safety of daily administration of capromorelin in cats"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-715X","authenticated-orcid":false,"given":"J. A.","family":"Wofford","sequence":"first","affiliation":[{"name":"Aratana Therapeutics, Inc.  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