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A total of seven adult healthy mares (<jats:italic>n<\/jats:italic>\u00a0=\u00a04\u20136\/treatment) were administered 3\u00a0\u03bcg<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>into one radiocarpal joint and<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>intravenously (i.v.) at 0 (control), 0.03, 0.1, 0.3, and 1\u00a0mg\/kg in a blinded, randomized, crossover design with at least 3\u00a0weeks washout between. Two investigators independently assigned pain scores (at rest, walk and trot) and lameness scores before and up to 48\u00a0hr after<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>. Responses to touching the joint skin to assess tactile allodynia, plasma, and synovial fluid (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>)<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>concentrations were determined before and up to 48\u00a0hr after<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>. Blood and<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>were collected for clinical laboratory evaluations before and up to 48\u00a0hr after<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>. Areas under the curves of pain and lameness scores were calculated and compared between control and treatments. Data were analyzed using repeated measures<jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>with Dunnett or Bonferroni post\u2010test.<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05 was considered significant. Data are mean\u00a0\u00b1\u00a0<jats:italic><jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content><\/jats:italic>. Compared to control, pain, lameness, and tactile allodynia were significantly lower with 1\u00a0mg\/kg<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>, but not the other doses. For 0.1, 0.3, and 1\u00a0mg\/kg<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>treatments, plasma terminal half\u2010lives were 13\u00a0\u00b1\u00a03, 13\u00a0\u00b1\u00a00.5, and 24\u00a0\u00b1\u00a05\u00a0hr, and clearances were 68\u00a0\u00b1\u00a015, 48\u00a0\u00b1\u00a05, and 14\u00a0\u00b1\u00a01 ml\u00a0hr<jats:sup>\u22121<\/jats:sup>\u00a0kg<jats:sup>\u22121<\/jats:sup>. The 1 mg\/kg<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>reached the<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>at high concentrations. There were no important anti\u2010inflammatory effects. In conclusion,<jats:styled-content style=\"fixed-case\">sEH<\/jats:styled-content>inhibition with<jats:italic>t<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TUCB<\/jats:styled-content>may provide analgesia in horses with inflammatory joint pain.<\/jats:p>","DOI":"10.1111\/jvp.12463","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T05:26:38Z","timestamp":1508909198000},"page":"230-238","source":"Crossref","is-referenced-by-count":23,"title":["Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor<i>t<\/i>\u2010<scp>TUCB<\/scp>in horses with experimentally induced radiocarpal synovitis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-9018","authenticated-orcid":false,"given":"A. G. 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