{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:39:36Z","timestamp":1787837976828,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008459","name":"University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>In equids, phenylbutazone at high doses induces gastric disease, primarily in the glandular portion of the stomach. However, the mechanism of nonsteroidal anti\u2010inflammatory drug (NSAID)\u2010induced gastric disease in horses has yet to be determined. While phenylbutazone\u2010associated ulceration is often attributed to a decrease in basal gastric prostaglandins, this has not been demonstrated in the horse. Twelve horses were randomly assigned to treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a06; 4.4\u00a0mg\/kg phenylbutazone PO in 20\u00a0ml molasses q 12\u00a0hr for 7\u00a0days) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a06; 20\u00a0ml molasses PO q 12\u00a0hr for 7\u00a0days) groups. Before treatment and 3 and 7\u00a0days after initiation of treatment, gastroscopy was performed and glandular gastric biopsies were collected and frozen at \u221280\u00b0C. Glandular disease was assessed on a scale of 0\u20134. Prostaglandin E<jats:sub>2<\/jats:sub>concentrations in biopsies were measured using a commercially available enzyme\u2010linked immunosorbent assay. All phenylbutazone\u2010treated horses developed grade \u22652 glandular disease. Prostaglandin concentrations increased over time (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0017), but there was no effect of treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.49). These findings indicate that despite induction of glandular disease grade \u22652, phenylbutazone did not decrease basal glandular gastric prostaglandin E<jats:sub>2<\/jats:sub>concentration.<\/jats:p>","DOI":"10.1111\/jvp.12464","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T04:06:47Z","timestamp":1510891607000},"page":"239-245","source":"Crossref","is-referenced-by-count":25,"title":["Phenylbutazone induces equine glandular gastric disease without decreasing prostaglandin E<sub>2<\/sub>concentrations"],"prefix":"10.1111","volume":"41","author":[{"given":"S. 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