{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:49:10Z","timestamp":1770220150790,"version":"3.49.0"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>To support their combined use, the objective of the study was to evaluate the effects of benazepril and pimobendan on serum angiotensin\u2010converting enzyme (ACE) activity in dogs. A total of 48 healthy beagle dogs were randomized into four groups (<jats:italic>n\u00a0<\/jats:italic>=\u00a012 per group) in a parallel\u2010group design study: A (control, placebo twice daily (BID)); B (0.5\u20131.0\u00a0mg\/kg benazepril once daily (SID) in the morning, placebo in the evening); C (0.25\u20130.5\u00a0mg\/kg benazepril BID); D (0.25\u20130.5\u00a0mg\/kg benazepril and 0.125\u20130.25\u00a0mg\/kg pimobendan, both BID). The test items were administered orally for 15\u00a0days. Serum ACE activity was measured on days 1 and 15. Groups B, C and D had significantly lower average serum ACE activity compared to baseline and to the control group, on both days 1 and 15. There were no significant differences in average ACE activity between groups B, C and D. Noninferiority of group C to B was demonstrated. In conclusion, 0.25\u20130.5\u00a0mg\/kg benazepril administered BID produced noninferior inhibition of serum ACE activity compared to 0.5\u20131.0\u00a0mg\/kg benazepril dosed SID. Pimobendan had no significant effect on benazepril's action on serum ACE activity. The results support the use of benazepril BID in dogs and in combination with pimobendan.<\/jats:p>","DOI":"10.1111\/jvp.12475","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T05:23:48Z","timestamp":1517549028000},"page":"485-489","source":"Crossref","is-referenced-by-count":3,"title":["Effect of benazepril and pimobendan on serum angiotensin\u2010converting enzyme activity in dogs"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-9015","authenticated-orcid":false,"given":"J. N.","family":"King","sequence":"first","affiliation":[{"name":"Companion Animal Development Elanco Animal Health Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Christinaz","sequence":"additional","affiliation":[{"name":"Centre de Recherche Sant\u00e9 Animale Elanco Animal Health St Aubin Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Strehlau","sequence":"additional","affiliation":[{"name":"Companion Animal Development Elanco Animal Health Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hornfeld","sequence":"additional","affiliation":[{"name":"Centre de Recherche Sant\u00e9 Animale Elanco Animal Health St Aubin Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0392.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2012.00768.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2018.19.1.117"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.2460\/ajvr.1995.56.12.1620","article-title":"Pharmacokinetics of the active metabolite of benazepril, benazeprilat, and inhibition of plasma angiotensin\u2010converting enzyme activity after single and repeated administrations to dogs","volume":"56","author":"King J. N.","year":"1995","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0022-3565(24)35393-5","article-title":"Benazeprilat disposition and effect in dogs revisited with a pharmacokinetic\/pharmacodynamic modelling approach","volume":"292","author":"Toutain P. L.","year":"2000","journal-title":"Journal of Pharmacology and Experimental Therapeutics"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T12:44:26Z","timestamp":1751287466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,2]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/jvp.12475"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12475","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,2]]}}}