{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:22:14Z","timestamp":1788790934306,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Medication control and doping control have been established in horse racing to ensure the integrity of the sport and the welfare of the horses. This ensures that horses do not compete under the influence of any drugs, including omeprazole, a therapeutic medication used to treat equine gastric ulcer syndrome. In this study, pharmacokinetic data were produced in equine plasma and urine following an oral administration of 4\u00a0mg\/kg of generic buffered formulation of omeprazole to six Thoroughbred horses in five daily doses to determine an appropriate screening limit and detection time in equine plasma and to assess whether the current detection time of 72\u00a0hr in equine urine would be applicable when an alternative omeprazole product is administered. <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> of 436\u20132,432\u00a0ng\/ml and <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u2013tau<\/jats:sub> of 1,476\u20134,371\u00a0ng\u00a0hr\u00a0ml<jats:sup>\u22121<\/jats:sup> were obtained for plasma and indicated, in conjunction with other published oral omeprazole studies, that an appropriate plasma screening limit would be 500\u00a0pg\/ml with a detection time of 48\u00a0hr. Urine analysis showed that omeprazole could be detected for up to 25\u00a0hr above the previously established urine screening limit of 500\u00a0pg\/ml and thus indicated that the detection time advice could be potentially reduced from 72 to 48\u00a0hr to allow more comprehensive treatment of gastric lesions.<\/jats:p>","DOI":"10.1111\/jvp.12491","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T05:02:42Z","timestamp":1519275762000},"page":"469-475","source":"Crossref","is-referenced-by-count":9,"title":["Re\u2010evaluation of the regulation of omeprazole in racehorses: An evidence\u2010based approach"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-9812","authenticated-orcid":false,"given":"M.","family":"Viljanto","sequence":"first","affiliation":[{"name":"LGC  Fordham Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hillyer","sequence":"additional","affiliation":[{"name":"British Horseracing Authority  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hincks","sequence":"additional","affiliation":[{"name":"LGC  Fordham Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pearce","sequence":"additional","affiliation":[{"name":"LGC  Fordham Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9443-2311","authenticated-orcid":false,"given":"S. W.","family":"Paine","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2003.tb11469.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12341"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb05171.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12371"},{"key":"e_1_2_7_6_1","unstructured":"Hannan C. Mason L. O'Connor M. &Barragry T.(2008)Controlling therapeutic substances \u2010 a European harmonised approach: Determination of the detection time for omeprazole in the horse In Proceedings of the 17th International Conference of Racing Analysts and Veterinarians Turkey 396\u2013401."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1992.tb04794.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2001.tb00095.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12328"},{"key":"e_1_2_7_10_1","first-page":"361","article-title":"Evaluation of the effect of omeprazole on physiological indices of performance of horses during incremental treadmill exercise","volume":"2","author":"Kollias\u2010Baker C.","year":"2001","journal-title":"Veterinary Therapeutics"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2006.tb05624.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516403775696339"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1996.tb03107.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13578"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12287"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jvp.12240","article-title":"Pharmacokinetics and bioequivalence testing of five commercial formulations of omeprazole in the horse","volume":"39","author":"Sykes B. 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