{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:32:08Z","timestamp":1779309128537,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Buprenorphine is a partial \u03bc agonist opioid used for analgesia in dogs. An extended\u2010release formulation (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010buprenorphine) has been shown to provide effective analgesia for 72\u00a0hr in rats and mice. Six healthy mongrel dogs were enrolled in a randomized, blinded crossover design to describe and compare the pharmacokinetics and pharmacodynamics of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010buprenorphine administered subcutaneous at 0.2\u00a0mg\/kg (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010B) and commercially available buprenorphine for injection intravenously at 0.02\u00a0mg\/kg (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010B). After drug administration, serial blood samples were collected to measure plasma buprenorphine concentrations using liquid chromatography\/mass spectrometry detection. Heart rate, respiratory rate, body temperature, sedation score, and thermal threshold latency were recorded throughout the study. Median (range) terminal half\u2010life, time to maximum concentration, and maximum plasma concentration of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010buprenorphine were 12.74\u00a0hr (10.43\u201318.84\u00a0hr), 8\u00a0hr (4\u201336\u00a0hr), and 5.00\u00a0ng\/ml (4.29\u201310.98\u00a0ng\/ml), respectively. Mild bradycardia, hypothermia, and inappetence were noted in both groups. Thermal threshold latency was significantly prolonged compared to baseline up to 12\u00a0hr and up to 72\u00a0hr in <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010B and <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010B, respectively. These results showed that <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010buprenorphine administered at a dose of 0.2\u00a0mg\/kg resulted in prolonged and sustained plasma concentrations and antinociceptive effects up to 72\u00a0hr after drug administration.<\/jats:p>","DOI":"10.1111\/jvp.12497","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T11:12:40Z","timestamp":1520593960000},"page":"502-512","source":"Crossref","is-referenced-by-count":12,"title":["The pharmacokinetics and analgesic effects of extended\u2010release buprenorphine administered subcutaneously in healthy dogs"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-3511","authenticated-orcid":false,"given":"M.","family":"Barletta","sequence":"first","affiliation":[{"name":"Department of Large Animal Medicine College of Veterinary Medicine University of Georgia  Athens GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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