{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:20:32Z","timestamp":1770628832615,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CREATE Fund NC State University CVM"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to describe the pharmacokinetics (PK) of cytarabine (CA) after subcutaneous (SC) administration to dogs with meningoencephalomyelitis of unknown etiology (MUE). Twelve dogs received a single SC dose of CA at 50\u00a0mg\/m<jats:sup>2<\/jats:sup>as part of treatment of MUE. A sparse sampling technique was used to collect four blood samples from each dog from 0 to 360\u00a0min after administration. All dogs were concurrently receiving prednisone (0.5\u20132\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>day<jats:sup>\u22121<\/jats:sup>). Plasma CA concentrations were measured by HPLC, and pharmacokinetic parameters were estimated using nonlinear mixed\u2010effects modeling (NLME). Plasma drug concentrations ranged from 0.05 to 2.8\u00a0\u03bcg\/ml. The population estimate (CV%) for elimination half\u2010life and Tmax of cytarabine in dogs was 1.09 (21.93) hr and 0.55 (51.03) hr, respectively. The volume of distribution per fraction absorbed was 976.31 (10.85%) ml\/kg. Mean plasma concentration of CA for all dogs was above 1.0\u00a0\u03bcg\/ml at the 30\u2010, 60\u2010, 90\u2010, and 120\u2010min time points. In this study, the pharmacokinetics of CA in dogs with MUE after a single 50\u00a0mg\/m<jats:sup>2<\/jats:sup>SC injection in dogs was similar to what has been previously reported in healthy beagles; there was moderate variability in the population estimates in this clinical population of dogs.<\/jats:p>","DOI":"10.1111\/jvp.12667","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T12:11:48Z","timestamp":1526386308000},"page":"638-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology"],"prefix":"10.1111","volume":"41","author":[{"given":"B.","family":"Pastina","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-8500","authenticated-orcid":false,"given":"P. J.","family":"Early","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. L.","family":"Bergman","sequence":"additional","affiliation":[{"name":"Carolina Veterinary Specialists Matthews North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Nettifee","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Maller","sequence":"additional","affiliation":[{"name":"Madison Veterinary Specialists Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Y.","family":"Bray","sequence":"additional","affiliation":[{"name":"Carolina Veterinary Specialists Winston Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Waldron","sequence":"additional","affiliation":[{"name":"Upstate Veterinary Specialist Greenville South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Castel","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Tennessee C247 Veterinary Teaching Hospital Knoxville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. R.","family":"Munana","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-7898","authenticated-orcid":false,"given":"M. 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