{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:11:32Z","timestamp":1790802692914,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31502125"],"award-info":[{"award-number":["31502125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030310086"],"award-info":[{"award-number":["2015A030310086"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pharmacokinetic (<jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content>) properties of enrofloxacin (<jats:styled-content style=\"fixed-case\">ENR<\/jats:styled-content>) and its metabolite ciprofloxacin (<jats:styled-content style=\"fixed-case\">CIP<\/jats:styled-content>) were investigated in crucian carp following oral administration at different dose levels (5, 10, 20, 40\u00a0mg\/kg body weight). The disposition kinetics of <jats:styled-content style=\"fixed-case\">ENR<\/jats:styled-content> was found to be linear over the dose range studied. Serum half\u2010lives ranged from 64.56 to 72.68\u00a0hr. The <jats:italic>in vitro<\/jats:italic> and ex vivo activities of <jats:styled-content style=\"fixed-case\">ENR<\/jats:styled-content> in serum against a pathogenic strain of <jats:italic>Aeromonas hydrophila<\/jats:italic> were determined. In vitro and ex vivo bactericidal activity of <jats:styled-content style=\"fixed-case\">ENR<\/jats:styled-content> was concentration dependent. Dosing of 10\u00a0mg\/kg resulted in an <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\/minimum inhibitory concentration (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>) ratio of 368.92\u00a0hr and a <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>\/<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> ratio of 7.23, respectively, against <jats:italic>A.\u00a0hydrophila<\/jats:italic> 147 (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>\u00a0=\u00a00.48\u00a0\u03bcg\/ml), indicating a likely high level of effectiveness in clinical infections caused by <jats:italic>A.\u00a0hydrophila<\/jats:italic> with <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> value\u00a0\u2264\u00a00.48\u00a0\u03bcg\/ml. Modeling of ex vivo growth inhibition data to the sigmoid Emax equation provided the values of <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>24\u00a0hr<\/jats:sub>\/<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> required to produce bacteriostasis, bactericidal activity, and elimination of bacteria, these values were 21.70, 53.01, and 125.21\u00a0hr, respectively. These findings in conjunction with <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content><jats:sub>90<\/jats:sub> data suggested that <jats:styled-content style=\"fixed-case\">ENR<\/jats:styled-content> at the dose of 7.81\u00a0mg\/kg predicted a positive clinical outcome and minimize the risk of emergence of resistance.<\/jats:p>","DOI":"10.1111\/jvp.12678","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T04:46:18Z","timestamp":1529988378000},"page":"887-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pharmacokinetic\/pharmacodynamic relationship of enrofloxacin against <i>Aeromonas hydrophila<\/i> in crucian carp (<i>Carassius auratus gibelio<\/i>)"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6095-3602","authenticated-orcid":false,"given":"Qi","family":"Shan","sequence":"first","affiliation":[{"name":"Key Laboratory of Recreational Fisheries Research Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality &amp; Safety Risky Assessment for Aquatic Product Pearl River Fisheries Research Institute Chinese Academic of Fishery Science  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Recreational Fisheries Research Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality &amp; Safety Risky Assessment for Aquatic Product Pearl River Fisheries Research Institute Chinese Academic of Fishery Science  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring Institute  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Recreational Fisheries Research Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality &amp; Safety Risky Assessment for Aquatic Product Pearl River Fisheries Research Institute Chinese Academic of Fishery Science  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring Institute  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Recreational Fisheries Research Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality &amp; Safety Risky Assessment for Aquatic Product Pearl River Fisheries Research Institute Chinese Academic of Fishery Science  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring Institute  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shugui","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Recreational Fisheries Research Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality &amp; Safety Risky Assessment for Aquatic Product Pearl River Fisheries Research Institute Chinese Academic of Fishery Science  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Recreational Fisheries Research Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality &amp; Safety Risky Assessment for Aquatic Product Pearl River Fisheries Research Institute Chinese Academic of Fishery Science  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Recreational Fisheries Research Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality &amp; Safety Risky Assessment for Aquatic Product Pearl River Fisheries Research Institute Chinese Academic of Fishery Science  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"347","article-title":"Detection and identification of virulent Yersinia ruckeri: The causative agent of enteric redmouth disease in rainbow trout (Oncorhynchus mykiss) cultured in Fars province, Iran","volume":"9","author":"Akhlaghi M.","year":"2008","journal-title":"Iranian Journal of Veterinary Research"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00503"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1577\/1548-8667(1994)006<0288:LEOEFT>2.3.CO;2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1992.tb00987.x"},{"key":"e_1_2_8_6_1","unstructured":"Chang C.S.(2009).Simultaneous determination of quinolones in marine and livestock products and pharmacokinetics of enrofloxacin in Tilapia. 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