{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:05:57Z","timestamp":1776452757244,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T00:00:00Z","timestamp":1541289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672599"],"award-info":[{"award-number":["31672599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pharmacokinetic parameters of moxidectin (<jats:styled-content style=\"fixed-case\">MXD<\/jats:styled-content>) after intravenous and pour\u2010on (topical) administration were studied in sixteen pigs at a single dose of 1.25 and 2.5\u00a0mg\/kg <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> (body weight), respectively. Blood samples were collected at pretreatment time (0\u00a0hr) over 40\u00a0days. The plasma kinetics were analyzed by WinNonlin 6.3 software through a noncompartmental model. For intravenous administration (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), the elimination half\u2010life (\u03bb<jats:sub>Z<\/jats:sub>), the apparent volume of distribution (V<jats:sub>z<\/jats:sub>), and clearance (Cl) were 10.29\u00a0\u00b1\u00a01.90\u00a0days, 89.575\u00a0\u00b1\u00a029.856\u00a0L\/kg, and 5.699\u00a0\u00b1\u00a02.374\u00a0L\/kg, respectively. For pour\u2010on administration (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), the maximum plasma drug concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>), time to maximum plasma concentration (<jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>), and \u03bb<jats:sub>Z<\/jats:sub> were 7.49\u00a0ng\/ml, 1.72, and 6.20\u00a0days, respectively. <jats:styled-content style=\"fixed-case\">MXD<\/jats:styled-content> had a considerably low absolute pour\u2010on bioavailability of 9.2%, but the mean residence time (<jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content>) for pour\u2010on administration 10.88\u00a0\u00b1\u00a01.75\u00a0days was longer than 8.99\u00a0\u00b1\u00a02.48\u00a0days for intravenous administration. These results showed that <jats:styled-content style=\"fixed-case\">MXD<\/jats:styled-content> was absorbed via skin rapidly and eliminated slowly. The obtained data might contribute to refine the dosage regime for topical <jats:styled-content style=\"fixed-case\">MXD<\/jats:styled-content> administration.<\/jats:p>","DOI":"10.1111\/jvp.12693","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T04:09:27Z","timestamp":1541390967000},"page":"111-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The pharmacokinetics of moxidectin following intravenous and topical administration to swine"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-8820","authenticated-orcid":false,"given":"Hongzhi","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology College of Veterinary Medicine China Agricultural University  Beijing China"},{"name":"Laboratory of Quality &amp; Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing) Ministry of Agriculture  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology College of Veterinary Medicine China Agricultural University  Beijing China"},{"name":"Laboratory of Quality &amp; Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing) Ministry of Agriculture  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology College of Veterinary Medicine China Agricultural University  Beijing China"},{"name":"Laboratory of Quality &amp; Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing) Ministry of Agriculture  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyuan","family":"kong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology College of Veterinary Medicine China Agricultural University  Beijing China"},{"name":"Laboratory of Quality &amp; Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing) Ministry of Agriculture  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology College of Veterinary Medicine China Agricultural University  Beijing China"},{"name":"Laboratory of Quality &amp; 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