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Net growth rate for<jats:italic>P.\u00a0multocida<\/jats:italic>in<jats:styled-content style=\"fixed-case\">CAMHB<\/jats:styled-content>was significantly slower than in<jats:styled-content style=\"fixed-case\">FBS<\/jats:styled-content>and higher than in<jats:styled-content style=\"fixed-case\">RPMI<\/jats:styled-content>, correlating to<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content>ranking.<jats:italic>Drug effect<\/jats:italic>: doxycycline<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s and<jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content>s were significantly lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) in both<jats:styled-content style=\"fixed-case\">CAMHB<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">FBS<\/jats:styled-content>than tetracycline and oxytetracycline for both pathogens. Only for<jats:italic>M.\u00a0haemolytica<\/jats:italic>were oxytetracycline<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content>significantly lower than tetracycline, precluding the use of tetracycline to predict oxytetracycline susceptibility in this species. Determining potencies of tetracyclines in a physiological medium, such as<jats:styled-content style=\"fixed-case\">FBS<\/jats:styled-content>, is proposed, when the objective is correlation with pharmacokinetic data for dosage determination.<\/jats:p>","DOI":"10.1111\/jvp.12719","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T05:04:52Z","timestamp":1538197492000},"page":"52-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens<i>Mannheimia haemolytica<\/i>and<i>Pasteurella multocida<\/i>in three growth media"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-3030","authenticated-orcid":false,"given":"Andrew","family":"Mead","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedical Sciences Royal Veterinary College Hatfield Herts UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lees","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences Royal Veterinary College Hatfield Herts UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Veterinary Medicines Directorate Addlestone Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Rycroft","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Science Royal Veterinary College Hatfield Herts UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph F.","family":"Standing","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-8892","authenticated-orcid":false,"given":"Pierre\u2010Louis","family":"Toutain","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences Royal Veterinary College Hatfield Herts UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Pelligand","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences Royal Veterinary College Hatfield Herts UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1979"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.08.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojas.2014.45041"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.100935"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2013.01.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis473"},{"key":"e_1_2_9_8_1","unstructured":"C. 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