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Mechanistically, the inhibition of\n                    <jats:styled-content style=\"fixed-case\">IMPDH<\/jats:styled-content>\n                    leads to the selective and eventual arrest of T\u2010 and B\u2010lymphocyte proliferation. Mycophenolate mofetil (\n                    <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>\n                    ), the first\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    \u2010based product to receive marketing approval over two decades ago, was originally indicated for the prophylaxis of organ rejection in human transplant patients. Given its broad immunosuppressive properties and ability to selectively inhibit lymphocyte division and effector functions, the clinical utility of\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    was subsequently explored in a host of autoimmune diseases. Human clinical studies have shown\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    to be safe and effective and support its off\u2010label administration for immune\u2010mediated diseases such as lupus, myasthenia gravis and atopic dermatitis.\n                    <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>\n                    became generically available in the United States in 2008, and its clinical utility is increasingly being explored as a treatment option for dogs with immune\u2010mediated diseases. This review summarizes the available literature for\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    pharmacokinetics and pharmacodynamics, and the current status of\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    as a treatment for client\u2010owned dogs diagnosed with immune\u2010mediated diseases.\n                  <\/jats:p>","DOI":"10.1111\/jvp.12731","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T02:57:21Z","timestamp":1540868241000},"page":"127-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mycophenolic acid in patients with immune\u2010mediated inflammatory diseases: From humans to dogs"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-8053","authenticated-orcid":false,"given":"Michael","family":"Klotsman","sequence":"first","affiliation":[{"name":"Okava Pharmaceuticals San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayatri","family":"Sathyan","sequence":"additional","affiliation":[{"name":"Okava Pharmaceuticals San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne H.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Okava Pharmaceuticals San Francisco California"},{"name":"Pulmonary and Critical Care Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver A.","family":"Garden","sequence":"additional","affiliation":[{"name":"Clinical Sciences &amp; Advanced Medicine University of Pennsylvania School of Veterinary Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmaja","family":"Shivanand","sequence":"additional","affiliation":[{"name":"Okava Pharmaceuticals San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0039-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00433.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12400"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00192309"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(00)00188-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.206"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.10.189"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2004.00318.x"},{"key":"e_1_2_11_10_1","first-page":"103","article-title":"The use of mycophenolate mofetil in the treatment of a case of immune\u2010mediated glomerulonephritis in a dog","volume":"31","author":"Banyard M. 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